| Literature DB >> 2997924 |
P Bullock, J J Champoux, M Botchan.
Abstract
Nonhomologous DNA recombination is frequently observed in somatic cells upon the introduction of DNA into cells or in chromosomal events involving sequences already stably carried by the genome. In this report, the DNA sequences at the crossover points for excision of SV40 from chromosomes were shown to be associated with eukaryotic topoisomerase I cleavage sites in vitro. The precise location of the cleavage sites relative to the crossover points has suggested a general model for nonhomologous recombination mediated by topoisomerase I.Mesh：
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Year: 1985 PMID： 2997924 DOI： 10.1126/science.2997924
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728