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Literature DB >> 1577469

Assignment of casein kinase 2 alpha sequences to two different human chromosomes.

B Boldyreff¹, C Klett, E Göttert, A Geurts van Kessel, H Hameister, O G Issinger.

Abstract

Human casein kinase 2 alpha gene (CK-2-alpha) sequences have been localized within the human genome by in situ hybridization and somatic cell hybrid analysis using a CK-2 alpha cDNA as a probe. By in situ hybridization, the CK-2 alpha cDNA could be assigned to two different loci, one on 11p15.1-ter and one on 20p13. The existence of two separate chromosomal loci suggests that CK-2 alpha is a member of a gene family. Only the locus on chromosome 11 was confirmed by somatic cell hybrid analysis. The analysis was based on the presence of a CK-2-alpha-specific 20-kb fragment. However, the CK-2 alpha cDNA hybridizes to several additional fragments in total human DNA.

Entities: Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1577469 DOI： 10.1007/bf00207047

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

Review 1. Casein kinase 2: an 'eminence grise' in cellular regulation?

Authors: L A Pinna
Journal: Biochim Biophys Acta Date: 1990-09-24

2. Assignment of the human casein kinase II beta-subunit gene to 6p12----p21.

Authors: T L Yang-Feng; T Teitz; M C Cheung; Y W Kan; D Canaani
Journal: Genomics Date: 1990-12 Impact factor: 5.736

3. Casein kinase II. cDNA sequences, developmental expression, and tissue distribution of mRNAs for alpha, alpha', and beta subunits of the chicken enzyme.

Authors: G Maridor; W Park; W Krek; E A Nigg
Journal: J Biol Chem Date: 1991-02-05 Impact factor: 5.157

4. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

Authors: F J Lozeman; D W Litchfield; C Piening; K Takio; K A Walsh; E G Krebs
Journal: Biochemistry Date: 1990-09-11 Impact factor: 3.162

5. Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae.

Authors: R Padmanabha; J L Chen-Wu; D E Hanna; C V Glover
Journal: Mol Cell Biol Date: 1990-08 Impact factor: 4.272

Assignment of casein kinase 2 alpha sequences to two different human chromosomes.

Review 1. Casein kinase 2: an 'eminence grise' in cellular regulation?

2. Assignment of the human casein kinase II beta-subunit gene to 6p12----p21.

3. Casein kinase II. cDNA sequences, developmental expression, and tissue distribution of mRNAs for alpha, alpha', and beta subunits of the chicken enzyme.

4. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

5. Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae.

6. Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.

7. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

8. Isolation and characterization of recombinant human casein kinase II subunits alpha and beta from bacteria.

9. Expression of human myeloid-associated surface antigens in human-mouse myeloid cell hybrids.

10. Enhanced casein kinase II activity in human tumour cell cultures.

1. Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α' levels.

2. PstI identifies biallelic DNA polymorphism of the human casein kinase 2 alpha gene (CSNK2A1).