Literature DB >> 2539275

Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine.

W K Seow1, A Ferrante, S Y Li, Y H Thong.   

Abstract

The bisbenzylisoquinoline alkaloid, tetrandrine, was shown to affect some important human monocyte functions. The drug caused significant inhibition of random movement, chemotaxis, superoxide anion generation and interleukin 1 (IL-1) production. By contrast, degranulation and hexose-monophosphate shunt activity were unaffected. Tetrandrine may be of value in the treatment of chronic inflammatory diseases where IL-1 has a major role as an inflammatory mediator.

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Year:  1989        PMID： 2539275      PMCID： PMC1541864     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  29 in total

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Journal:  J Immunol       Date:  1986-04-15       Impact factor: 5.422

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Journal:  J Pathol       Date:  1984-11       Impact factor: 7.996

6.  Separation and characterization of human neutrophil granules.

Authors:  B C West; A S Rosenthal; N A Gelb; H R Kimball
Journal:  Am J Pathol       Date:  1974-10       Impact factor: 4.307

7.  Studies on the contents of glycosaminoglycans from lungs of silicotic rats and tetrandrine-treated silicotic rats.

Authors:  B C Liu; C Q Zou; Y R Li
Journal:  Ecotoxicol Environ Saf       Date:  1983-06       Impact factor: 6.291

8.  Enhancement of base hexose-monophosphate shunt activity of human polymorphonuclear leucocytes by human beta-interferon.

Authors:  A Ferrante; V O Rencis
Journal:  Immunol Lett       Date:  1984       Impact factor: 3.685

9.  Fibroblast RNA and macrophage proteins (including the fibrogenic factor) in experimental silicosis.

Authors:  E Kulonen; M Aalto; S Aho; P Lehtinen; M Potila
Journal:  Environ Health Perspect       Date:  1983-09       Impact factor: 9.031

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Authors:  A C Allison; J S Harington; M Birbeck
Journal:  J Exp Med       Date:  1966-08-01       Impact factor: 14.307
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  7 in total

1.  Characterization of the major neutrophil-stimulating activity present in culture medium conditioned by Staphylococcus aureus-stimulated mononuclear leucocytes.

Authors:  E J Bates; A Ferrante; L J Beard
Journal:  Immunology       Date:  1991-03       Impact factor: 7.397

2.  Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats.

Authors:  M W Whitehouse; D P Fairlie; Y H Thong
Journal:  Agents Actions       Date:  1994-10

3.  Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes.

Authors:  A Ferrante; W K Seow; B Rowan-Kelly; Y H Thong
Journal:  Clin Exp Immunol       Date:  1990-05       Impact factor: 4.330

4.  Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor.

Authors:  C W Wong; W K Seow; J W O'Callaghan; Y H Thong
Journal:  Agents Actions       Date:  1992-05

5.  Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys.

Authors:  Zuguang Ye; Knox Van Dyke; Richard N Rossan
Journal:  Malar J       Date:  2013-04-02       Impact factor: 2.979

6.  Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.

Authors:  W K Seow; K Nakamura; Y Sugimura; Y Sugimoto; Y Yamada; D P Fairlie; Y H Thong
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711

Review 7.  Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19.

Authors:  Paula M Heister; Robin N Poston
Journal:  Pharmacol Res Perspect       Date:  2020-10
  7 in total

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