Literature DB >> 18475522

Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.

W K Seow1, K Nakamura, Y Sugimura, Y Sugimoto, Y Yamada, D P Fairlie, Y H Thong.   

Abstract

Synthesis of IL-1beta and TNFalpha by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the muM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.

Entities:  

Year:  1993        PMID： 18475522      PMCID： PMC2365410          DOI： 10.1155/S0962935193000262

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  22 in total

1.  Comparative effects of tetrandrine and berbamine on acute and relapsing experimental allergic encephalitis in Lewis rats.

Authors:  C W Wong; W K Seow; Y H Thong
Journal:  Int Arch Allergy Immunol       Date:  1992       Impact factor: 2.749

2.  Proinflammatory cytokines in acute asthma.

Authors:  P H Brown; G K Crompton; A P Greening
Journal:  Lancet       Date:  1991-09-07       Impact factor: 79.321

3.  Prevention by tetrandrine of spontaneous development of diabetes mellitus in BB rats.

Authors:  I Lieberman; D P Lentz; G A Trucco; W K Seow; Y H Thong
Journal:  Diabetes       Date:  1992-05       Impact factor: 9.461

4.  Comparative immunopharmacology and toxicology of the bisbenzylisoquinoline alkaloids tetrandrine and berbamine.

Authors:  C W Wong; W K Seow; T S Zeng; W J Halliday; Y H Thong
Journal:  Int J Immunopharmacol       Date:  1991

5.  Defining protective responses to pathogens: cytokine profiles in leprosy lesions.

Authors:  M Yamamura; K Uyemura; R J Deans; K Weinberg; T H Rea; B R Bloom; R L Modlin
Journal:  Science       Date:  1991-10-11       Impact factor: 47.728

6.  Histamine release inhibition activity of bisbenzylisoquinoline alkaloids.

Authors:  K Nakamura; S Tsuchiya; Y Sugimoto; Y Sugimura; Y Yamada
Journal:  Planta Med       Date:  1992-12       Impact factor: 3.352

7.  Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1 and tumor necrosis factor.

Authors:  W K Seow; A Ferrante; A Summors; Y H Thong
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

8.  Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor.

Authors:  C W Wong; W K Seow; J W O'Callaghan; Y H Thong
Journal:  Agents Actions       Date:  1992-05

9.  Demonstration of the induction of apoptosis (programmed cell death) by tetrandrine, a novel anti-inflammatory agent.

Authors:  B S Teh; P Chen; M F Lavin; W K Seow; Y H Thong
Journal:  Int J Immunopharmacol       Date:  1991

10.  Epithelial ovarian cancer: a cytokine propelled disease?

Authors:  S Malik; F Balkwill
Journal:  Br J Cancer       Date:  1991-10       Impact factor: 7.640
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  3 in total

1.  Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats.

Authors:  M W Whitehouse; D P Fairlie; Y H Thong
Journal:  Agents Actions       Date:  1994-10

2.  Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach.

Authors:  Andréa Aparecida Santos Mendonça; Camila Morais Coelho; Marcia Paranho Veloso; Ivo Santana Caldas; Reggiani Vilela Gonçalves; Antônio Lucio Teixeira; Aline Silva de Miranda; Rômulo Dias Novaes
Journal:  Oxid Med Cell Longev       Date:  2018-10-24       Impact factor: 6.543

3.  Spectral, Anti-Inflammatory, Anti-Pyretic, Leishmanicidal, and Molecular Docking Studies, Against Selected Protein Targets, of a New Bisbenzylisoquinoline Alkaloid.

Authors:  Muhammad Alamzeb; William N Setzer; Saqib Ali; Behramand Khan; Mamoon-Ur- Rashid; Syed Muhammad Salman; Muhammad Omer; Javed Ali; Asad Ullah
Journal:  Front Chem       Date:  2021-12-17       Impact factor: 5.221
  3 in total

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