Literature DB >> 2357850

Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes.

A Ferrante1, W K Seow, B Rowan-Kelly, Y H Thong.   

Abstract

Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concentration range of 0.1 to 5 micrograms/ml. Tetrandrine may be potentially useful in the treatment of inflammatory diseases in which TNF-alpha plays a major role.

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Year:  1990        PMID： 2357850      PMCID： PMC1535282          DOI： 10.1111/j.1365-2249.1990.tb05239.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  24 in total

1.  Inhibition of histamine release from rat mast cells by the plant alkaloid tetrandrine.

Authors:  B S Teh; W K Seow; A H Chalmers; S Playford; B Ioannoni; Y H Thong
Journal:  Int Arch Allergy Appl Immunol       Date:  1988

2.  IgG subclass assays with polyclonal antisera and monoclonal antibodies.

Authors:  A Ferrante; L J Beard
Journal:  Monogr Allergy       Date:  1988

3.  The role of cell injury and the continuing inflammatory response in the generation of silicotic pulmonary fibrosis.

Authors:  D H Bowden; I Y Adamson
Journal:  J Pathol       Date:  1984-11       Impact factor: 7.996

4.  Antiphagocytic and antioxidant properties of plant alkaloid tetrandrine.

Authors:  W K Seow; A Ferrante; S Y Li; Y H Thong
Journal:  Int Arch Allergy Appl Immunol       Date:  1988

5.  Macrophage-neutrophil interactions: contrasting effects of the monokines interleukin-1 and tumour necrosis factor (cachectin) on human neutrophil adherence.

Authors:  W K Seow; Y H Thong; A Ferrante
Journal:  Immunology       Date:  1987-11       Impact factor: 7.397

6.  In vitro immunosuppressive properties of the plant alkaloid tetrandrine.

Authors:  W K Seow; A Ferrante; D B Goh; A H Chalmers; S Y Li; Y H Thong
Journal:  Int Arch Allergy Appl Immunol       Date:  1988

7.  Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

Authors:  S W Lee; A P Tsou; H Chan; J Thomas; K Petrie; E M Eugui; A C Allison
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

8.  Staphylococcus aureus-stimulated human mononuclear leucocyte-conditioned medium augments the basal and stimuli-induced neutrophil respiratory burst and degranulation.

Authors:  A Ferrante; M Nandoskar; E J Bates; D H Goh
Journal:  Immunology       Date:  1987-03       Impact factor: 7.397

9.  Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

Authors:  M C Cuturi; M Murphy; M P Costa-Giomi; R Weinmann; B Perussia; G Trinchieri
Journal:  J Exp Med       Date:  1987-06-01       Impact factor: 14.307

10.  Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

Authors:  J Vilcek; V J Palombella; D Henriksen-DeStefano; C Swenson; R Feinman; M Hirai; M Tsujimoto
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307
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  11 in total

1.  Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.

Authors:  A Ferrante; R E Staugas; B Rowan-Kelly; S Bresatz; L M Kumaratilake; C M Rzepczyk; G R Adolf
Journal:  Infect Immun       Date:  1990-12       Impact factor: 3.441

2.  Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats.

Authors:  M W Whitehouse; D P Fairlie; Y H Thong
Journal:  Agents Actions       Date:  1994-10

3.  Dual effects of tetrandrine on cytosolic calcium in human leukaemic HL-60 cells: intracellular calcium release and calcium entry blockade.

Authors:  Y M Leung; C Y Kwan; T T Loh
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

4.  Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor.

Authors:  C W Wong; W K Seow; J W O'Callaghan; Y H Thong
Journal:  Agents Actions       Date:  1992-05

5.  Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives.

Authors:  Sarwar Beg; Suryakanta Swain; Hameed Hasan; M Abul Barkat; Md Sarfaraz Hussain
Journal:  Pharmacogn Rev       Date:  2011-07

Review 6.  Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II.

Authors:  M Akhtar Anwar; Sara S Al Disi; Ali H Eid
Journal:  Front Pharmacol       Date:  2016-03-08       Impact factor: 5.810

7.  Combination Nanotherapeutics for Dry Eye Disease Treatment in a Rabbit Model.

Authors:  Liandi Huang; Huanhuan Gao; Zhigang Wang; Yixin Zhong; Lan Hao; Zhiyu Du
Journal:  Int J Nanomedicine       Date:  2021-05-26

8.  Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.

Authors:  W K Seow; K Nakamura; Y Sugimura; Y Sugimoto; Y Yamada; D P Fairlie; Y H Thong
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711

9.  Tetrandrine Exerts a Radiosensitization Effect on Human Glioma through Inhibiting Proliferation by Attenuating ERK Phosphorylation.

Authors:  Ji-Wei Ma; Yong Zhang; Ji-Cheng Ye; Ru Li; Yu-Lin Wen; Jian-Xian Huang; Xue-Yun Zhong
Journal:  Biomol Ther (Seoul)       Date:  2017-03-01       Impact factor: 4.634

Review 10.  Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19.

Authors:  Paula M Heister; Robin N Poston
Journal:  Pharmacol Res Perspect       Date:  2020-10
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