Literature DB >> 2528694

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis.

J Ostermann1, A L Horwich, W Neupert, F U Hartl.   

Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

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Year:  1989        PMID： 2528694     DOI： 10.1038/341125a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  188 in total

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