Literature DB >> 1349170

What drives the translocation of proteins?

S M Simon1, C S Peskin, G F Oster.   

Abstract

We propose that protein translocation across membranes is driven by biased random thermal motion. This "Brownian ratchet" mechanism depends on chemical asymmetries between the cis and trans sides of the membrane. Several mechanisms could contribute to rectifying the thermal motion of the protein, such as binding and dissociation of chaperonins to the translocating chain, chain coiling induced by pH and/or ionic gradients, glycosylation, and disulfide bond formation. This helps explain the robustness and promiscuity of these transport systems.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1349170      PMCID： PMC525572          DOI： 10.1073/pnas.89.9.3770

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

1.  Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.

Authors:  P J Kang; J Ostermann; J Shilling; W Neupert; E A Craig; N Pfanner
Journal:  Nature       Date:  1990-11-08       Impact factor: 49.962

Review 2.  The structure and insertion of integral proteins in membranes.

Authors:  S J Singer
Journal:  Annu Rev Cell Biol       Date:  1990

Review 3.  Ras C-terminal processing enzymes--new drug targets?

Authors:  J B Gibbs
Journal:  Cell       Date:  1991-04-05       Impact factor: 41.582

4.  Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences.

Authors:  J Martin; K Mahlke; N Pfanner
Journal:  J Biol Chem       Date:  1991-09-25       Impact factor: 5.157

Review 5.  Protein motors and Maxwell's demons: does mechanochemical transduction involve a thermal ratchet?

Authors:  R D Vale; F Oosawa
Journal:  Adv Biophys       Date:  1990

6.  Energy requirements for unfolding and membrane translocation of precursor proteins during import into mitochondria.

Authors:  N Pfanner; J Rassow; B Guiard; T Söllner; F U Hartl; W Neupert
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

7.  Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes.

Authors:  V R Lingappa; J Chaidez; C S Yost; J Hedgpeth
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

8.  Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein.

Authors:  V R Lingappa; J R Lingappa; R Prasad; K E Ebner; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

9.  A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.

Authors:  P E Scherer; U C Krieg; S T Hwang; D Vestweber; G Schatz
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598

10.  Chemical factors that influence nucleocytoplasmic transport: a fluorescence photobleaching study.

Authors:  L W Jiang; M Schindler
Journal:  J Cell Biol       Date:  1986-03       Impact factor: 10.539
View more
  116 in total

1.  Two distinct mechanisms drive protein translocation across the mitochondrial outer membrane in the late step of the cytochrome b(2) import pathway.

Authors:  M Esaki; T Kanamori; S i Nishikawa; T Endo
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

2.  Driven polymer translocation through a narrow pore.

Authors:  D K Lubensky; D R Nelson
Journal:  Biophys J       Date:  1999-10       Impact factor: 4.033

Review 3.  Protein unfolding by mitochondria. The Hsp70 import motor.

Authors:  A Matouschek; N Pfanner; W Voos
Journal:  EMBO Rep       Date:  2000-11       Impact factor: 8.807

4.  The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products.

Authors:  C M Story; M H Furman; H L Ploegh
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

5.  Diffusion of green fluorescent protein in the aqueous-phase lumen of endoplasmic reticulum.

Authors:  M J Dayel; E F Hom; A S Verkman
Journal:  Biophys J       Date:  1999-05       Impact factor: 4.033

6.  Models of post-translational protein translocation.

Authors:  T C Elston
Journal:  Biophys J       Date:  2000-11       Impact factor: 4.033

7.  The brownian ratchet and power stroke models for posttranslational protein translocation into the endoplasmic reticulum.

Authors:  Timothy C Elston
Journal:  Biophys J       Date:  2002-03       Impact factor: 4.033

8.  A plastid enzyme arrested in the step of precursor translocation in vivo.

Authors:  S Reinbothe; C Reinbothe; D Neumann; K Apel
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

9.  Kinetics and mechanism of DNA uptake into the cell nucleus.

Authors:  H Salman; D Zbaida; Y Rabin; D Chatenay; M Elbaum
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-05       Impact factor: 11.205

10.  Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.

Authors:  Vivek Sharma; Arulandu Arockiasamy; Donald R Ronning; Christos G Savva; Andreas Holzenburg; Miriam Braunstein; William R Jacobs; James C Sacchettini
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-26       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.