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Literature DB >> 25220675

tRNA fragments in human health and disease.

Abstract

Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have demonstrated that tRNAs also serve as a major source of small non-coding RNAs that possess distinct and varied functions. These tRNA fragments are heterogeneous in size, nucleotide composition, biogenesis and function. Here we describe multiple roles that tRNA fragments play in cell physiology and discuss their relevance to human health and disease.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Angiogenin; Apoptosis; RNA processing; Stress; Transfer RNA; tRNA-derived fragment

Mesh：

Substances：
RNA, Transfer

Year: 2014 PMID： 25220675 PMCID： PMC4339185 DOI： 10.1016/j.febslet.2014.09.001

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

101 in total

1. HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

Authors: Johannes Popow; Markus Englert; Stefan Weitzer; Alexander Schleiffer; Beata Mierzwa; Karl Mechtler; Simon Trowitzsch; Cindy L Will; Reinhard Lührmann; Dieter Söll; Javier Martinez
Journal: Science Date: 2011-02-11 Impact factor: 47.728

2. Angiogenin protects motoneurons against hypoxic injury.

Authors: J Sebastià; D Kieran; B Breen; M A King; D F Netteland; D Joyce; S F Fitzpatrick; C T Taylor; J H M Prehn
Journal: Cell Death Differ Date: 2009-05-15 Impact factor: 15.828

3. High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma.

Authors: Ying Zhou; Jeffrey M Goodenbour; Lucy A Godley; Amittha Wickrema; Tao Pan
Journal: Biochem Biophys Res Commun Date: 2009-05-19 Impact factor: 3.575

4. Patterns of urinary excretion of modified nucleosides.

Authors: C W Gehrke; K C Kuo; T P Waalkes; E Borek
Journal: Cancer Res Date: 1979-04 Impact factor: 12.701

5. Control of motoneuron survival by angiogenin.

Authors: Dairín Kieran; Jordi Sebastia; Matthew J Greenway; Matthew A King; Dervla Connaughton; Caoimhin G Concannon; Beau Fenner; Orla Hardiman; Jochen H M Prehn
Journal: J Neurosci Date: 2008-12-24 Impact factor: 6.167

6. A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.

Authors: Richard Y T Kao; Jeremy L Jenkins; Karen A Olson; Marc E Key; James W Fett; Robert Shapiro
Journal: Proc Natl Acad Sci U S A Date: 2002-07-12 Impact factor: 11.205

7. Conformational change in transfer RNA is an early indicator of acute cellular damage.

Authors: Eikan Mishima; Chisako Inoue; Daisuke Saigusa; Ryusuke Inoue; Koki Ito; Yusuke Suzuki; Daisuke Jinno; Yuri Tsukui; Yosuke Akamatsu; Masatake Araki; Kimi Araki; Ritsuko Shimizu; Haruka Shinke; Takehiro Suzuki; Yoichi Takeuchi; Hisato Shima; Yasutoshi Akiyama; Takafumi Toyohara; Chitose Suzuki; Yoshikatu Saiki; Teiji Tominaga; Shigehito Miyagi; Naoki Kawagisihi; Tomoyoshi Soga; Takayoshi Ohkubo; Kenichi Yamamura; Yutaka Imai; Satohiro Masuda; Venkata Sabbisetti; Takaharu Ichimura; David B Mount; Joseph V Bonventre; Sadayoshi Ito; Yoshihisa Tomioka; Kunihiko Itoh; Takaaki Abe
Journal: J Am Soc Nephrol Date: 2014-05-15 Impact factor: 10.121

Review 8. Small silencing RNAs: an expanding universe.

Authors: Megha Ghildiyal; Phillip D Zamore
Journal: Nat Rev Genet Date: 2009-02 Impact factor: 53.242

9. Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells.

Authors: Andrew Sobala; Gyorgy Hutvagner
Journal: RNA Biol Date: 2013-04-01 Impact factor: 4.652

10. Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid.

Authors: Man Lung Yeung; Yamina Bennasser; Koichi Watashi; Shu-Yun Le; Laurent Houzet; Kuan-Teh Jeang
Journal: Nucleic Acids Res Date: 2009-09-03 Impact factor: 16.971

166 in total

1. Emerging Roles of tRNA-derived Fragments in Viral Infections: The Case of Respiratory Syncytial Virus.

Authors: Pavel Ivanov
Journal: Mol Ther Date: 2015-10 Impact factor: 11.454

Review 2. Every little piece counts: the many faces of tRNA transcripts.

Authors: David Lalaouna; Marie-Claude Carrier; Eric Massé
Journal: Transcription Date: 2015

3. tRNA^Arg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation.

Authors: Irem Avcilar-Kucukgoze; Howard Gamper; Christine Polte; Zoya Ignatova; Ralph Kraetzner; Michael Shtutman; Ya-Ming Hou; Dawei W Dong; Anna Kashina
Journal: Cell Chem Biol Date: 2020-06-16 Impact factor: 8.116

4. Removing roadblocks to deep sequencing of modified RNAs.

Authors: Jeremy E Wilusz
Journal: Nat Methods Date: 2015-09 Impact factor: 28.547

5. Huntington's disease brain-derived small RNAs recapitulate associated neuropathology in mice.

Authors: Jordi Creus-Muncunill; Anna Guisado-Corcoll; Veronica Venturi; Lorena Pantano; Georgia Escaramís; Marta García de Herreros; Maria Solaguren-Beascoa; Ana Gámez-Valero; Cristina Navarrete; Mercè Masana; Franc Llorens; Daniela Diaz-Lucena; Esther Pérez-Navarro; Eulàlia Martí
Journal: Acta Neuropathol Date: 2021-02-06 Impact factor: 17.088

6. PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.

Authors: Zhangping He; Shuliang Jing; Tao Yang; Jingliang Chen; Feng Huang; Wanying Zhang; Zhilin Peng; Bingfeng Liu; Xiancai Ma; Liyang Wu; Ting Pan; Xu Zhang; Linghua Li; Weiping Cai; Xiaoping Tang; Junsong Zhang; Hui Zhang
Journal: J Virol Date: 2020-05-04 Impact factor: 5.103