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Literature DB >> 25482014

Stress granules, P-bodies and cancer.

Paul Anderson¹, Nancy Kedersha², Pavel Ivanov³.

Abstract

Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic machinery, and stress response programs. This review examines evidence implicating RNA granules in the pathogenesis of cancer and discusses their potential as targets for anticancer therapies. This article is part of a Special Issue entitled: Translation and Cancer.

Entities: CellLine Chemical Disease Gene Species

Keywords: Apoptosis; Cancer; P-body; Post-transcriptional regulation; Stress granule; Stress response

Mesh：

Substances：
RNA, Neoplasm

Year: 2014 PMID： 25482014 PMCID： PMC4457708 DOI： 10.1016/j.bbagrm.2014.11.009

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

171 in total

1. Stress granule assembly is mediated by prion-like aggregation of TIA-1.

Authors: Natalie Gilks; Nancy Kedersha; Maranatha Ayodele; Lily Shen; Georg Stoecklin; Laura M Dember; Paul Anderson
Journal: Mol Biol Cell Date: 2004-09-15 Impact factor: 4.138

Review 2. Structural and functional insights into eukaryotic mRNA decapping.

Authors: Sharon H M Ling; Rohini Qamra; Haiwei Song
Journal: Wiley Interdiscip Rev RNA Date: 2010-09-02 Impact factor: 9.957

Review 3. P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.

Authors: Carolyn J Decker; Roy Parker
Journal: Cold Spring Harb Perspect Biol Date: 2012-09-01 Impact factor: 10.005

Review 4. Mechanisms of deadenylation-dependent decay.

Authors: Chyi-Ying A Chen; Ann-Bin Shyu
Journal: Wiley Interdiscip Rev RNA Date: 2010-09-15 Impact factor: 9.957

5. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.

Authors: Martin Fenger-Grøn; Christy Fillman; Bodil Norrild; Jens Lykke-Andersen
Journal: Mol Cell Date: 2005-12-22 Impact factor: 17.970

6. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing.

Authors: Ana Eulalio; Isabelle Behm-Ansmant; Daniel Schweizer; Elisa Izaurralde
Journal: Mol Cell Biol Date: 2007-04-02 Impact factor: 4.272

7. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.

Authors: Kathrin Thedieck; Birgit Holzwarth; Mirja Tamara Prentzell; Christopher Boehlke; Kathrin Kläsener; Stefanie Ruf; Annika Gwendolin Sonntag; Lars Maerz; Sushma-Nagaraja Grellscheid; Elisabeth Kremmer; Roland Nitschke; E Wolfgang Kuehn; Johan W Jonker; Albert K Groen; Michael Reth; Michael N Hall; Ralf Baumeister
Journal: Cell Date: 2013-08-15 Impact factor: 41.582

8. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.

Authors: Sohee Kwon; Yu Zhang; Patrick Matthias
Journal: Genes Dev Date: 2007-12-15 Impact factor: 11.361

9. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.

Authors: Nader Ezzeddine; Tsung-Cheng Chang; Wenmiao Zhu; Akio Yamashita; Chyi-Ying A Chen; Zhenping Zhong; Yukiko Yamashita; Dinghai Zheng; Ann-Bin Shyu
Journal: Mol Cell Biol Date: 2007-09-04 Impact factor: 4.272

10. The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells.

Authors: María Angel García; Esther Carrasco; Margarita Aguilera; Pablo Alvarez; Carmen Rivas; Joaquin María Campos; Jose Carlos Prados; Miguel Angel Calleja; Mariano Esteban; Juan Antonio Marchal; Antonia Aránega
Journal: PLoS One Date: 2011-08-24 Impact factor: 3.240

148 in total

1. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.

Authors: J Gavin Daigle; Karthik Krishnamurthy; Nandini Ramesh; Ian Casci; John Monaghan; Kevin McAvoy; Earl W Godfrey; Dianne C Daniel; Edward M Johnson; Zachary Monahan; Frank Shewmaker; Piera Pasinelli; Udai Bhan Pandey
Journal: Acta Neuropathol Date: 2016-01-04 Impact factor: 17.088

2. DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.

Authors: Deanna M Patmore; Amir Jassim; Erica Nathan; Reuben J Gilbertson; Daniel Tahan; Nadin Hoffmann; Yiai Tong; Kyle S Smith; Thirumala-Devi Kanneganti; Hiromichi Suzuki; Michael D Taylor; Paul Northcott; Richard J Gilbertson
Journal: Dev Cell Date: 2020-06-17 Impact factor: 12.270

Review 10. Long noncoding RNA turnover.

Authors: Je-Hyun Yoon; Jiyoung Kim; Myriam Gorospe
Journal: Biochimie Date: 2015-03-10 Impact factor: 4.079

Stress granules, P-bodies and cancer.

1. Stress granule assembly is mediated by prion-like aggregation of TIA-1.

Review 2. Structural and functional insights into eukaryotic mRNA decapping.

Review 3. P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.

Review 4. Mechanisms of deadenylation-dependent decay.

5. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.

6. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing.

7. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.

8. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.

9. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.

10. The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells.

1. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.

2. DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.

Review 3. Translational Control under Stress: Reshaping the Translatome.

Review 4. New Insights into the Functions of Nucleic Acids Controlled by Cellular Microenvironments.

5. Stress-specific differences in assembly and composition of stress granules and related foci.

6. FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins.

7. Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules.

8. Gle1 mediates stress granule-dependent survival during chemotoxic stress.

9. The Activity-Dependent Regulation of Protein Kinase Stability by the Localization to P-Bodies.

Review 10. Long noncoding RNA turnover.