Literature DB >> 2521477

The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

G Lindahl1, E Gersdorf, H J Menzel, C Duba, H Cleve, S Humphries, G Utermann.   

Abstract

We have studied the segregation of the Lp(a) glycoprotein phenotypes and of the plasminogen (PLG) polymorphism in three two-generation families. The inheritance of the Lp(a) gene was followed using the Lp(a) glycoprotein size polymorphism and that of the plasminogen gene, using protein and DNA polymorphisms. In the three families studied, no recombination was observed in 18 meioses. The lod score for linkage between the Lp(a) glycoprotein locus and the plasminogen locus in these families is greater than 5.0 at a recombination fraction of theta = 0. Our results show that the structural gene for the Lp(a) glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

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Year:  1989        PMID： 2521477     DOI： 10.1007/bf00293891

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  29 in total

1.  Genetics of the quantitative Lp(a) lipoprotein trait. II. Inheritance of Lp(a) glycoprotein phenotypes.

Authors:  G Utermann; C Duba; H J Menzel
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

2.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

3.  Genetics of the quantitative Lp(a) lipoprotein trait. I. Relation of LP(a) glycoprotein phenotypes to Lp(a) lipoprotein concentrations in plasma.

Authors:  G Utermann; H G Kraft; H J Menzel; T Hopferwieser; C Seitz
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

4.  Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma.

Authors:  G Utermann; H J Menzel; H G Kraft; H C Duba; H G Kemmler; C Seitz
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

5.  cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

Authors:  J W McLean; J E Tomlinson; W J Kuang; D L Eaton; E Y Chen; G M Fless; A M Scanu; R M Lawn
Journal:  Nature       Date:  1987 Nov 12-18       Impact factor: 49.962

6.  Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

Authors:  J C Murray; K H Buetow; M Donovan; S Hornung; A G Motulsky; C Disteche; K Dyer; K Swisshelm; J Anderson; E Giblett
Journal:  Am J Hum Genet       Date:  1987-04       Impact factor: 11.025

7.  Genetic polymorphism of human plasminogen.

Authors:  M J Hobart
Journal:  Ann Hum Genet       Date:  1979-05       Impact factor: 1.670

8.  Heterogeneity of human plasma lipoprotein (a). Isolation and characterization of the lipoprotein subspecies and their apoproteins.

Authors:  G M Fless; C A Rolih; A M Scanu
Journal:  J Biol Chem       Date:  1984-09-25       Impact factor: 5.157

9.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

10.  Isolation and characterization of the two major apoproteins in human lipoprotein [a].

Authors:  J W Gaubatz; M V Chari; M L Nava; J R Guyton; J D Morrisett
Journal:  J Lipid Res       Date:  1987-01       Impact factor: 5.922
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  17 in total

1.  Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.

Authors:  C Lackner; E Boerwinkle; C C Leffert; T Rahmig; H H Hobbs
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

2.  Expressed hypervariable polymorphism of apolipoprotein (a).

Authors:  M I Kamboh; R E Ferrell; B A Kottke
Journal:  Am J Hum Genet       Date:  1991-11       Impact factor: 11.025

3.  Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.

Authors:  K C Ehrlich; M Ehrlich
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

Review 4.  Lipoprotein (a). Heterogeneity and biological relevance.

Authors:  A M Scanu; G M Fless
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

Review 5.  Structure, function, and genetics of lipoprotein (a).

Authors:  Konrad Schmidt; Asma Noureen; Florian Kronenberg; Gerd Utermann
Journal:  J Lipid Res       Date:  2016-04-13       Impact factor: 5.922

6.  The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration.

Authors:  H G Kraft; S Köchl; H J Menzel; C Sandholzer; G Utermann
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132

Review 7.  Lipoprotein(a): new insights into an atherogenic lipoprotein.

Authors:  W Bartens; C Wanner
Journal:  Clin Investig       Date:  1994-08

8.  Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.

Authors:  C A DeMeester; X Bu; R J Gray; A J Lusis; J I Rotter
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

9.  Characterization of the enzyme activity of human plasma lipoprotein (a) using synthetic peptide substrates.

Authors:  M Jauhiainen; J Metso; P Koskinen; C Ehnholm
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

Review 10.  Lipoprotein(a) and its role in occlusive vascular disease.

Authors:  M Tennant; J K McGeachie
Journal:  Ann R Coll Surg Engl       Date:  1993-01       Impact factor: 1.891
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