Literature DB >> 27074913

Structure, function, and genetics of lipoprotein (a).

Konrad Schmidt1, Asma Noureen2, Florian Kronenberg2, Gerd Utermann3.   

Abstract

Lipoprotein (a) [Lp(a)] has attracted the interest of researchers and physicians due to its intriguing properties, including an intragenic multiallelic copy number variation in the LPA gene and the strong association with coronary heart disease (CHD). This review summarizes present knowledge of the structure, function, and genetics of Lp(a) with emphasis on the molecular and population genetics of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology. It highlights the role of genetics in establishing Lp(a) as a risk factor for CHD, but also discusses uncertainties, controversies, and lack of knowledge on several aspects of the genetic Lp(a) trait, not least its function.
Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Mendelian randomization; cardiovascular risk factor; copy number variation; lipoprotein metabolism

Mesh：

Substances：

Year:  2016        PMID： 27074913      PMCID： PMC4959873          DOI： 10.1194/jlr.R067314

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  241 in total

1.  Urinary excretion of apo(a) fragments. Role in apo(a) catabolism.

Authors:  K M Kostner; G Maurer; K Huber; T Stefenelli; H Dieplinger; E Steyrer; G M Kostner
Journal:  Arterioscler Thromb Vasc Biol       Date:  1996-08       Impact factor: 8.311

2.  Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.

Authors:  C Lackner; E Boerwinkle; C C Leffert; T Rahmig; H H Hobbs
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

3.  The conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor V.

Authors:  C T Esmon; C M Jackson
Journal:  J Biol Chem       Date:  1974-12-25       Impact factor: 5.157

Review 4.  The seventh myth of lipoprotein(a): where and how is it assembled?

Authors:  H Dieplinger; G Utermann
Journal:  Curr Opin Lipidol       Date:  1999-06       Impact factor: 4.776

5.  Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a).

Authors:  Gregor Leibundgut; Corey Scipione; Huiyong Yin; Matthias Schneider; Michael B Boffa; Simone Green; Xiaohong Yang; Edward Dennis; Joseph L Witztum; Marlys L Koschinsky; Sotirios Tsimikas
Journal:  J Lipid Res       Date:  2013-07-04       Impact factor: 5.922

6.  Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB.

Authors:  Y Y van der Hoek; A Lingenhel; H G Kraft; J C Defesche; J J Kastelein; G Utermann
Journal:  J Clin Invest       Date:  1997-05-01       Impact factor: 14.808

7.  Lipoprotein(a) and apolipoprotein(a) isoforms: no association with coronary artery calcification in the Dallas Heart Study.

Authors:  Rudy Guerra; Zhaoxia Yu; Santica Marcovina; Ronald Peshock; Jonathan C Cohen; Helen H Hobbs
Journal:  Circulation       Date:  2005-03-21       Impact factor: 29.690

8.  Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study.

Authors:  Fangwen Rao; Andrew J Schork; Adam X Maihofer; Caroline M Nievergelt; Santica M Marcovina; Elizabeth R Miller; Joseph L Witztum; Daniel T O'Connor; Sotirios Tsimikas
Journal:  Arterioscler Thromb Vasc Biol       Date:  2015-05-07       Impact factor: 8.311

9.  Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction.

Authors:  Stephan R Holmer; Christian Hengstenberg; Hans-Georg Kraft; Björn Mayer; Melanie Pöll; Susanne Kürzinger; Marcus Fischer; Hannelore Löwel; Gernot Klein; Günter A J Riegger; Heribert Schunkert
Journal:  Circulation       Date:  2003-02-11       Impact factor: 29.690

10.  A global reference for human genetic variation.

Authors:  Adam Auton; Lisa D Brooks; Richard M Durbin; Erik P Garrison; Hyun Min Kang; Jan O Korbel; Jonathan L Marchini; Shane McCarthy; Gil A McVean; Gonçalo R Abecasis
Journal:  Nature       Date:  2015-10-01       Impact factor: 49.962
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  95 in total

1.  A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population.

Authors:  Yibin Liu; Hongkun Ma; Qian Zhu; Bin Zhang; Hong Yan; Hanping Li; Jinxiu Meng; Weihua Lai; Liwen Li; Danqing Yu; Shilong Zhong
Journal:  J Lipid Res       Date:  2019-06-11       Impact factor: 5.922

2.  Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a).

Authors:  Ayelet Gonen; Xiaohong Yang; Calvin Yeang; Elena Alekseeva; Marlys Koschinsky; Joseph L Witztum; Michael Boffa; Sotirios Tsimikas
Journal:  J Lipid Res       Date:  2020-07-08       Impact factor: 5.922

Review 3.  Genetics of Dyslipidemia and Ischemic Heart Disease.

Authors:  Kavita Sharma; Ragavendra R Baliga
Journal:  Curr Cardiol Rep       Date:  2017-05       Impact factor: 2.931

4.  Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431 239 Patients.

Authors:  Patrick M Moriarty; Stephen A Varvel; Philip L S M Gordts; Joseph P McConnell; Sotirios Tsimikas
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-01-05       Impact factor: 8.311

Review 5.  Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.

Authors:  Børge G Nordestgaard; Anne Langsted
Journal:  J Lipid Res       Date:  2016-09-27       Impact factor: 5.922

6.  LPA kringle IV type 2 is associated with type 2 diabetes in a Chinese population with very high cardiovascular risk.

Authors:  Di-Li-Da-Er Mu-Han-Ha-Li 迪丽达尔 木汗哈力; Tian-Yu Zhai 翟天羽; Yan Ling 凌雁; Xin Gao 高鑫
Journal:  J Lipid Res       Date:  2018-03-06       Impact factor: 5.922

7.  In search of a physiological function of lipoprotein(a): causality of elevated Lp(a) levels and reduced incidence of type 2 diabetes.

Authors:  Sotirios Tsimikas
Journal:  J Lipid Res       Date:  2018-04-02       Impact factor: 5.922

8.  Circulating oxidized LDL, increased in patients with acute myocardial infarction, is accompanied by heavily modified HDL.

Authors:  Naoko Sawada; Takashi Obama; Shinji Koba; Takashi Takaki; Sanju Iwamoto; Toshihiro Aiuchi; Rina Kato; Masaki Kikuchi; Yuji Hamazaki; Hiroyuki Itabe
Journal:  J Lipid Res       Date:  2020-04-14       Impact factor: 5.922

Review 9.  Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Authors:  Sotirios Tsimikas
Journal:  Circ Res       Date:  2019-02       Impact factor: 17.367

Review 10.  The Riskier Lipid: What Is on the HORIZON for Lipoprotein (a) and Should There Be Lp(a) Screening for All?

Authors:  Stephen J Nicholls; Kristen J Bubb
Journal:  Curr Cardiol Rep       Date:  2021-07-01       Impact factor: 2.931
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