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Literature DB >> 2388631

Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.

Abstract

Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1990 PMID： 2388631 PMCID： PMC361120 DOI： 10.1128/mcb.10.9.4957-4960.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

26 in total

1. The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

Authors: G Lindahl; E Gersdorf; H J Menzel; C Duba; H Cleve; S Humphries; G Utermann
Journal: Hum Genet Date: 1989-01 Impact factor: 4.132

2. Methylated DNA-binding protein is present in various mammalian cell types.

Authors: P C Supakar; D Weist; D L Zhang; N Inamdar; X Y Zhang; R Khan; K C Ehrlich; M Ehrlich
Journal: Nucleic Acids Res Date: 1988-08-25 Impact factor: 16.971

3. Structural relationship of an apolipoprotein (a) phenotype (570 kDa) to plasminogen: homologous kringle domains are linked by carbohydrate-rich regions.

Authors: H Kratzin; V W Armstrong; M Niehaus; N Hilschmann; D Seidel
Journal: Biol Chem Hoppe Seyler Date: 1987-12

4. Related sites in human and herpesvirus DNA recognized by methylated DNA-binding protein from human placenta.

Authors: X Y Zhang; P C Supakar; R Khan; K C Ehrlich; M Ehrlich
Journal: Nucleic Acids Res Date: 1989-02-25 Impact factor: 16.971

5. An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

Authors: S E Hyman; M Comb; J Pearlberg; H M Goodman
Journal: Mol Cell Biol Date: 1989-01 Impact factor: 4.272

Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.

1. The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

2. Methylated DNA-binding protein is present in various mammalian cell types.

3. Structural relationship of an apolipoprotein (a) phenotype (570 kDa) to plasminogen: homologous kringle domains are linked by carbohydrate-rich regions.

4. Related sites in human and herpesvirus DNA recognized by methylated DNA-binding protein from human placenta.

5. An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

6. Human methylated DNA-binding protein. Determinants of a pBR322 recognition site.

7. Rhesus monkey apolipoprotein(a). Sequence, evolution, and sites of synthesis.

8. Apolipoprotein(a) (Apo(a)) glycoprotein isoforms result from size differences in Apo(a) mRNA in baboons.

9. Genetic linkage between lipoprotein(a) phenotype and a DNA polymorphism in the plasminogen gene.

10. The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1. A nuclear protein with enhanced binding to methylated Sp1 sites in the AIDS virus promoter.

2. Binding sites in mammalian genes and viral gene regulatory regions recognized by methylated DNA-binding protein.

3. RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.