Literature DB >> 2828221

Genetics of the quantitative Lp(a) lipoprotein trait. II. Inheritance of Lp(a) glycoprotein phenotypes.

G Utermann1, C Duba, H J Menzel.   

Abstract

Lp(a) glycoprotein exhibits an apparent size polymorphism that is associated with genetically controlled Lp(a) lipoprotein concentrations in plasma (Utermann et al. 1988). We have tested the hypothesis that this polymorphism is genetically controlled by studying 15 matings with a total of 44 offspring. This confirmed our conclusion that Lp(a) types are controlled by a series of codominant alleles LpF, LpB, LpS1, LpS2, LpS3 and LpS4 and by a null allele LpO. Together with the data from the accompanying paper this indicates that the structural gene for the Lp(a) protein is the major gene locus determining Lp(a) lipoprotein concentrations in plasma.

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Year:  1988        PMID： 2828221     DOI： 10.1007/BF00291233

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  29 in total

1.  Genetics of the quantitative Lp(a) lipoprotein trait. I. Relation of LP(a) glycoprotein phenotypes to Lp(a) lipoprotein concentrations in plasma.

Authors:  G Utermann; H G Kraft; H J Menzel; T Hopferwieser; C Seitz
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

2.  Protein and carbohydrate composition of Lp(a)lipoprotein from human plasma.

Authors:  C Ehnholm; H Garoff; O Renkonen; K Simons
Journal:  Biochemistry       Date:  1972-08-15       Impact factor: 3.162

3.  Sensitive visualization of antigen-antibody reactions in dot and blot immune overlay assays with immunogold and immunogold/silver staining.

Authors:  M Moeremans; G Daneels; A Van Dijck; G Langanger; J De Mey
Journal:  J Immunol Methods       Date:  1984-11-30       Impact factor: 2.303

4.  Human plasma lipoprotein [a]. Structural properties.

Authors:  J W Gaubatz; C Heideman; A M Gotto; J D Morrisett; G H Dahlen
Journal:  J Biol Chem       Date:  1983-04-10       Impact factor: 5.157

5.  Immunohistochemical localization of barley stripe mosaic virions in infected wheat cells.

Authors:  N S Lin; W G Langenberg
Journal:  J Ultrastruct Res       Date:  1983-07

6.  Studies of Lp-lipoprotein as a quantitative genetic trait.

Authors:  N R Harvie; J S Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1970-05       Impact factor: 11.205

7.  Heterogeneity of human plasma lipoprotein (a). Isolation and characterization of the lipoprotein subspecies and their apoproteins.

Authors:  G M Fless; C A Rolih; A M Scanu
Journal:  J Biol Chem       Date:  1984-09-25       Impact factor: 5.157

8.  Isolation and characterization of the two major apoproteins in human lipoprotein [a].

Authors:  J W Gaubatz; M V Chari; M L Nava; J R Guyton; J D Morrisett
Journal:  J Lipid Res       Date:  1987-01       Impact factor: 5.922

9.  Protein composition of Lp(a) lipoprotein from human plasma.

Authors:  G Utermann; W Weber
Journal:  FEBS Lett       Date:  1983-04-18       Impact factor: 4.124

10.  Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp.

Authors:  D L Rainwater; G S Manis; R S Kushwaha
Journal:  Biochim Biophys Acta       Date:  1986-06-11
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  28 in total

1.  Changes in Lp(a) lipoprotein levels during the treatment of hypercholesterolaemia with simvastatin.

Authors:  L Slunga; O Johnson; G H Dahlén
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Characterization by yeast artificial chromosome cloning of the linked apolipoprotein(a) and plasminogen genes and identification of the apolipoprotein(a) 5' flanking region.

Authors:  N Malgaretti; F Acquati; P Magnaghi; L Bruno; M Pontoglio; M Rocchi; S Saccone; G Della Valle; M D'Urso; D LePaslier
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

Review 3.  Genetic basis of lipoprotein disorders.

Authors:  J L Breslow
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

4.  The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

Authors:  G Lindahl; E Gersdorf; H J Menzel; C Duba; H Cleve; S Humphries; G Utermann
Journal:  Hum Genet       Date:  1989-01       Impact factor: 4.132

5.  Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.

Authors:  C Lackner; E Boerwinkle; C C Leffert; T Rahmig; H H Hobbs
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

6.  Expressed hypervariable polymorphism of apolipoprotein (a).

Authors:  M I Kamboh; R E Ferrell; B A Kottke
Journal:  Am J Hum Genet       Date:  1991-11       Impact factor: 11.025

7.  Enhanced macrophage uptake of lipoprotein(a) after Ca2+-induced aggregate-formation.

Authors:  S Tanaka; A Yashiro; H Tasaki; Y Nakashima
Journal:  Lipids       Date:  1998-04       Impact factor: 1.880

8.  Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart disease.

Authors:  C Sandholzer; E Boerwinkle; N Saha; M C Tong; G Utermann
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808

9.  Serum LP(A) levels in randomized healthy men from different European countries.

Authors:  M Cigolini; J C Seidell; M G Zenti; G Bonadonna; L Zambelli; J P Deslypere; F Contaldo; A Cruz; J Charzewska; G Targher
Journal:  Eur J Epidemiol       Date:  1993-09       Impact factor: 8.082

10.  Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations.

Authors:  E Boerwinkle; C C Leffert; J Lin; C Lackner; G Chiesa; H H Hobbs
Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808
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