Literature DB >> 25132691

Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.

John R Goodell1, Bo Leng1, Tracy K Snyder1, Aaron B Beeler1, John A Porco1.   

Abstract

Multidimensional reaction screening employing complex 1,2-cycloheptanediones is described. The studies have enabled the discovery of regioselective, Lewis acid-mediated condensations with substituted ureas and a diastereoselective hydrogenation process which proceeds via an interesting allylpalladium hydride isomerization.

Entities:  

Keywords:  Lewis acids; diastereoselective hydrogenation; reaction discovery; regioselective condensation

Year:  2010        PMID： 25132691      PMCID： PMC4132846          DOI： 10.1055/s-0029-1218813

Source DB:  PubMed          Journal:  Synthesis (Stuttg)        ISSN： 0039-7881            Impact factor:   3.157


  18 in total

1.  Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.

Authors:  Giulio G Muccioli; Nicola Fazio; Gerhard K E Scriba; Wolfgang Poppitz; Fabio Cannata; Jacques H Poupaert; Johan Wouters; Didier M Lambert
Journal:  J Med Chem       Date:  2006-01-12       Impact factor: 7.446

2.  Discovery of chemical reactions through multidimensional screening.

Authors:  Aaron B Beeler; Shun Su; Chris A Singleton; John A Porco
Journal:  J Am Chem Soc       Date:  2007-02-07       Impact factor: 15.419

3.  Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.

Authors:  Zhijian Zhao; Ronald G Robinson; Stanley F Barnett; Deborah Defeo-Jones; Raymond E Jones; George D Hartman; Hans E Huber; Mark E Duggan; Craig W Lindsley
Journal:  Bioorg Med Chem Lett       Date:  2007-11-13       Impact factor: 2.823

4.  Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation.

Authors:  Hidenori Kinoshita; Oscar J Ingham; Winnie W Ong; Aaron B Beeler; John A Porco
Journal:  J Am Chem Soc       Date:  2010-05-12       Impact factor: 15.419

5.  Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

Authors:  John R Goodell; Jonathan P McMullen; Nikolay Zaborenko; Jason R Maloney; Chuan-Xing Ho; Klavs F Jensen; John A Porco; Aaron B Beeler
Journal:  J Org Chem       Date:  2009-08-21       Impact factor: 4.354

6.  Crowded Cu(I) complexes involving benzo[h]quinoline: pi-stacking effects and long-lives excited states.

Authors:  E C Riesgo; Y Z Hu; F Bouvier; R P Thummel; D V Scaltrito; G J Meyer
Journal:  Inorg Chem       Date:  2001-07-02       Impact factor: 5.165

7.  Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers.

Authors:  Jennifer L Treece; John R Goodell; David Vander Velde; John A Porco; Jeffrey Aubé
Journal:  J Org Chem       Date:  2010-03-19       Impact factor: 4.354

8.  Multicomponent reaction discovery: three-component synthesis of spirooxindoles.

Authors:  Bo Liang; Srinivas Kalidindi; John A Porco; Corey R J Stephenson
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005

9.  Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.

Authors:  Moorthy S S Palanki; Elena Dneprovskaia; John Doukas; Richard M Fine; John Hood; Xinshan Kang; Dan Lohse; Michael Martin; Glenn Noronha; Richard M Soll; Wolfgang Wrasidlo; Shiyin Yee; Hong Zhu
Journal:  J Med Chem       Date:  2007-08-09       Impact factor: 7.446

10.  Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.

Authors:  Frank Rong; Suetying Chow; Shunqi Yan; Gary Larson; Zhi Hong; Jim Wu
Journal:  Bioorg Med Chem Lett       Date:  2007-01-08       Impact factor: 2.823
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  3 in total

1.  Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes.

Authors:  John R Goodell; Jennifer L Poole; Aaron B Beeler; Jeffrey Aubé; John A Porco
Journal:  J Org Chem       Date:  2011-11-01       Impact factor: 4.354

2.  Remodelling of the natural product fumagillol employing a reaction discovery approach.

Authors:  Bradley R Balthaser; Meghan C Maloney; Aaron B Beeler; John A Porco; John K Snyder
Journal:  Nat Chem       Date:  2011-12       Impact factor: 24.427

3.  Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes.

Authors:  Véronique I Martin; John R Goodell; Oscar J Ingham; John A Porco; Aaron B Beeler
Journal:  J Org Chem       Date:  2014-04-16       Impact factor: 4.354
  3 in total

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