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Literature DB >> 20560568

Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

John R Goodell¹, Jonathan P McMullen, Nikolay Zaborenko, Jason R Maloney, Chuan-Xing Ho, Klavs F Jensen, John A Porco, Aaron B Beeler.

Abstract

An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 20560568 PMCID： PMC2976622 DOI： 10.1021/jo901073v

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

41 in total

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3. Transport and reaction in microscale segmented gas-liquid flow.

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4. Rapid, automated screening method for enzymatic transformations using a robotic system and supercritical fluid chromatography.

Authors: Li Di; Oliver J McConnell; Edward H Kerns; Alan G Sutherland
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Review 6. Reactions in droplets in microfluidic channels.

Authors: Helen Song; Delai L Chen; Rustem F Ismagilov
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7. An approach to skeletal diversity using functional group pairing of multifunctional scaffolds.

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8. Flash chemistry: fast chemical synthesis by using microreactors.

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Review 9. Diversity-oriented synthesis; a spectrum of approaches and results.

Authors: Richard J Spandl; Andreas Bender; David R Spring
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10. Convenient synthesis of trans-beta-amino carboxylic esters with an azetidine skeleton via rearrangement of beta,gamma-aziridino alpha-amino esters.

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22 in total

Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

Review 1. Target-oriented and diversity-oriented organic synthesis in drug discovery.

Review 2. Technological advances in high-throughput screening.

3. Transport and reaction in microscale segmented gas-liquid flow.

4. Rapid, automated screening method for enzymatic transformations using a robotic system and supercritical fluid chromatography.

5. Synthesis and analysis of combinatorial libraries performed in an automated micro reactor system.

Review 6. Reactions in droplets in microfluidic channels.

7. An approach to skeletal diversity using functional group pairing of multifunctional scaffolds.

8. Flash chemistry: fast chemical synthesis by using microreactors.

Review 9. Diversity-oriented synthesis; a spectrum of approaches and results.

10. Convenient synthesis of trans-beta-amino carboxylic esters with an azetidine skeleton via rearrangement of beta,gamma-aziridino alpha-amino esters.

1. Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes.

Review 2. The past, present and potential for microfluidic reactor technology in chemical synthesis.

Review 3. Contemporary screening approaches to reaction discovery and development.

4. Visible-light photoredox catalysis in flow.

5. Discovery of an α-amino C-H arylation reaction using the strategy of accelerated serendipity.

6. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.

7. The Development of Visible-Light Photoredox Catalysis in Flow.

8. The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.

9. Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity.

10. Total Internal Reflection Transient Absorption Microscopy: An Online Detection Method for Microfluidics.