Literature DB >> 20050598

Multicomponent reaction discovery: three-component synthesis of spirooxindoles.

Bo Liang1, Srinivas Kalidindi, John A Porco, Corey R J Stephenson.   

Abstract

The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20050598      PMCID： PMC2814073          DOI： 10.1021/ol902764k

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  13 in total

1.  Facile, Novel Methodology for the Synthesis of Spiro

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  1999-11-02       Impact factor: 15.336

2.  DNA as a template for reaction discovery.

Authors:  Scott J Miller
Journal:  Nat Biotechnol       Date:  2004-11       Impact factor: 54.908

3.  Synthesis and cellular profiling of diverse organosilicon small molecules.

Authors:  Annaliese K Franz; Philip D Dreyfuss; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2007-02-07       Impact factor: 15.419

4.  Discovery of chemical reactions through multidimensional screening.

Authors:  Aaron B Beeler; Shun Su; Chris A Singleton; John A Porco
Journal:  J Am Chem Soc       Date:  2007-02-07       Impact factor: 15.419

5.  Efficient synthesis of spiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-tetraones by a one-pot and three-component reaction.

Authors:  Khosrow Jadidi; Ramin Ghahremanzadeh; Ayoob Bazgir
Journal:  J Comb Chem       Date:  2009 May-Jun

6.  Substitution and cyclization reactions involving the quasi-antiaromatic 2H-indol-2-one ring system.

Authors:  Dylan B England; Gokce Merey; Albert Padwa
Journal:  Org Lett       Date:  2007-08-21       Impact factor: 6.005

7.  Concise, asymmetric total synthesis of spirotryprostatin A.

Authors:  Tomoyuki Onishi; Paul R Sebahar; Robert M Williams
Journal:  Org Lett       Date:  2003-08-21       Impact factor: 6.005

8.  Stereocontrolled synthesis of spirooxindoles through Lewis acid-promoted [5 + 2]-annulation of chiral silyl alcohols.

Authors:  Yun Zhang; James S Panek
Journal:  Org Lett       Date:  2009-08-06       Impact factor: 6.005

9.  Stereoselective synthesis of spirooxindoles by palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with isatins.

Authors:  Ryo Shintani; Shin-ya Hayashi; Masataka Murakami; Momotaro Takeda; Tamio Hayashi
Journal:  Org Lett       Date:  2009-08-20       Impact factor: 6.005

Review 10.  Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.

Authors:  Chris V Galliford; Karl A Scheidt
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336
View more
  15 in total

1.  Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes.

Authors:  John R Goodell; Jennifer L Poole; Aaron B Beeler; Jeffrey Aubé; John A Porco
Journal:  J Org Chem       Date:  2011-11-01       Impact factor: 4.354

2.  A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions.

Authors:  Nazia Kausar; Abdulla Al Masum; Md Maidul Islam; Asish R Das
Journal:  Mol Divers       Date:  2017-02-11       Impact factor: 2.943

3.  Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates.

Authors:  John M Knapp; James C Fettinger; Mark J Kurth
Journal:  Org Lett       Date:  2011-08-09       Impact factor: 6.005

4.  One-pot synthesis of novel 1-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives via an Ugi-azide 4CR process.

Authors:  Mehdi Ghandi; Saleh Salahi; Abuzar Taheri; Alireza Abbasi
Journal:  Mol Divers       Date:  2017-12-11       Impact factor: 2.943

5.  Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.

Authors:  John R Goodell; Bo Leng; Tracy K Snyder; Aaron B Beeler; John A Porco
Journal:  Synthesis (Stuttg)       Date:  2010-07-01       Impact factor: 3.157

6.  Stereoselective synthesis of spirooxindole amides through nitrile hydrozirconation.

Authors:  Chunliang Lu; Qing Xiao; Paul E Floreancig
Journal:  Org Lett       Date:  2010-10-20       Impact factor: 6.005

7.  Highly stereoselective Brønsted acid catalyzed synthesis of spirooxindole pyrans.

Authors:  Jingqi Wang; Erika A Crane; Karl A Scheidt
Journal:  Org Lett       Date:  2011-05-18       Impact factor: 6.005

Review 8.  The molecular diversity scope of 1,3-indandione in organic synthesis.

Authors:  Shima Asadi; Ghodsi Mohammadi Ziarani
Journal:  Mol Divers       Date:  2015-05-10       Impact factor: 2.943

9.  FeCl₃-catalyzed [3+3] annulation between 3-oxirane-indolin-2-ones and nitrones to construct spiro[1,4,2-dioxazinan]oxindoles.

Authors:  Jingmiao Yu; Chun Cai
Journal:  Mol Divers       Date:  2017-04-24       Impact factor: 2.943

Review 10.  Molecular diversity of spirooxindoles. Synthesis and biological activity.

Authors:  Tetyana L Pavlovska; Ruslan Gr Redkin; Victoria V Lipson; Dmytro V Atamanuk
Journal:  Mol Divers       Date:  2015-09-29       Impact factor: 2.943
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.