Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.

Literature DB >> 17258458

Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.

Frank Rong¹, Suetying Chow, Shunqi Yan, Gary Larson, Zhi Hong, Jim Wu.

Abstract

From chemical compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, we identified a substituted quinoxaline hit with an IC(50) of 5.5 microM. A series of substituted quinoxaline amide derivatives were synthesized based on the hit's pharmacophore, and a good structure-activity relationship was observed. Computer modeling analysis was employed to help comprehend the SAR.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17258458 DOI： 10.1016/j.bmcl.2006.12.103

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

8 in total

1. Studies of new peroxyoxalate-H2O2 chemiluminescence system using quinoxaline derivatives as green fluorophores.

Authors: Abdolraouf Samadi-Maybodi; Reza Akhoondi; Mohammad Javad Chaichi
Journal: J Fluoresc Date: 2010-03-10 Impact factor: 2.217

2. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.

Authors: John R Goodell; Bo Leng; Tracy K Snyder; Aaron B Beeler; John A Porco
Journal: Synthesis (Stuttg) Date: 2010-07-01 Impact factor: 3.157

3. Pd/C-catalyzed, copper-free Sonogashira coupling: one-pot synthesis of 1-aryl-4-(2-phenylethynyl)[1,2,4]triazolo[4,3-a]quinoxalines in water.

Authors: Mohammad Bakherad; Saeideh Jajarmi
Journal: Monatsh Chem Date: 2013-02-14 Impact factor: 1.451

4. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.

Authors: Lei You; Eun Jeong Cho; John Leavitt; Li-Chung Ma; Gaetano T Montelione; Eric V Anslyn; Robert M Krug; Andrew Ellington; Jon D Robertus
Journal: Bioorg Med Chem Lett Date: 2011-03-17 Impact factor: 2.823

5. Highly efficient synthesis of quinoxaline derivatives from 1,2-benzenediamine and α-aminoxylated 1,3-dicarbonyl compounds.

Authors: Jianwei Yan; Yanhong Xu; Fangfang Zhuang; Jie Tian; Guisheng Zhang
Journal: Mol Divers Date: 2016-01-21 Impact factor: 2.943

Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.

1. Studies of new peroxyoxalate-H2O2 chemiluminescence system using quinoxaline derivatives as green fluorophores.

2. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.

3. Pd/C-catalyzed, copper-free Sonogashira coupling: one-pot synthesis of 1-aryl-4-(2-phenylethynyl)[1,2,4]triazolo[4,3-a]quinoxalines in water.

4. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.

5. Highly efficient synthesis of quinoxaline derivatives from 1,2-benzenediamine and α-aminoxylated 1,3-dicarbonyl compounds.

6. Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.

7. Construction of a novel quinoxaline as a new class of Nrf2 activator.

8. Natural vs. Synthetic Phosphate as Efficient Heterogeneous Compounds for Synthesis of Quinoxalines.