Literature DB >> 17263426

Discovery of chemical reactions through multidimensional screening.

Aaron B Beeler1, Shun Su, Chris A Singleton, John A Porco.   

Abstract

Multidimensional reaction screening of ortho-alkynyl benzaldehydes with a variety of catalysts and reaction partners was conducted in an effort to identify new chemical reactions. Reactions affording unique products were selected for investigation of preliminary scope and limitations.

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Year:  2007        PMID： 17263426     DOI： 10.1021/ja0674744

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  34 in total

1.  Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers.

Authors:  Suwei Dong; Katharine J Cahill; Moon-Il Kang; Nancy H Colburn; Curtis J Henrich; Jennifer A Wilson; John A Beutler; Richard P Johnson; John A Porco
Journal:  J Org Chem       Date:  2011-10-07       Impact factor: 4.354

2.  Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.

Authors:  Paul A Clemons; Nicole E Bodycombe; Hyman A Carrinski; J Anthony Wilson; Alykhan F Shamji; Bridget K Wagner; Angela N Koehler; Stuart L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-18       Impact factor: 11.205

3.  Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes.

Authors:  John R Goodell; Jennifer L Poole; Aaron B Beeler; Jeffrey Aubé; John A Porco
Journal:  J Org Chem       Date:  2011-11-01       Impact factor: 4.354

Review 4.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

5.  Discovery of new antimalarial chemotypes through chemical methodology and library development.

Authors:  Lauren E Brown; Ken Chih-Chien Cheng; Wan-Guo Wei; Pingwei Yuan; Peng Dai; Richard Trilles; Feng Ni; Jing Yuan; Ryan MacArthur; Rajarshi Guha; Ronald L Johnson; Xin-zhuan Su; Melissa M Dominguez; John K Snyder; Aaron B Beeler; Scott E Schaus; James Inglese; John A Porco
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-15       Impact factor: 11.205

Review 6.  Contemporary screening approaches to reaction discovery and development.

Authors:  Karl D Collins; Tobias Gensch; Frank Glorius
Journal:  Nat Chem       Date:  2014-10       Impact factor: 24.427

7.  Discovery of an α-amino C-H arylation reaction using the strategy of accelerated serendipity.

Authors:  Andrew McNally; Christopher K Prier; David W C MacMillan
Journal:  Science       Date:  2011-11-25       Impact factor: 47.728

8.  Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation.

Authors:  Hidenori Kinoshita; Oscar J Ingham; Winnie W Ong; Aaron B Beeler; John A Porco
Journal:  J Am Chem Soc       Date:  2010-05-12       Impact factor: 15.419

9.  Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents.

Authors:  Mary M Rozenman; Matthew W Kanan; David R Liu
Journal:  J Am Chem Soc       Date:  2007-11-10       Impact factor: 15.419

10.  Multicomponent reaction discovery: three-component synthesis of spirooxindoles.

Authors:  Bo Liang; Srinivas Kalidindi; John A Porco; Corey R J Stephenson
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005
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