Literature DB >> 3492043

Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.

D F Stern, D L Hare, M A Cecchini, R A Weinberg.   

Abstract

The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.

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Year:  1987        PMID： 3492043     DOI： 10.1126/science.3492043

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  33 in total

1.  Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types.

Authors:  A L Boerger; S Snitkovsky; J A Young
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.

Authors:  S l Fu; I Bottoli; M Goller; P K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

3.  The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors.

Authors:  A M Sizeland; A W Burgess
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

4.  EGFs and ERBBs--brief history and prospects.

Authors:  David F Stern
Journal:  Semin Cell Dev Biol       Date:  2010-10-21       Impact factor: 7.727

5.  p21ras-induced responsiveness of phosphatidylinositol turnover to bradykinin is a receptor number effect.

Authors:  J Downward; J de Gunzburg; R Riehl; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

6.  Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.

Authors:  B M Burgering; A J Snijders; J A Maassen; A J van der Eb; J L Bos
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

7.  Tumorigenic conversion of NIH 3T3 cells by transfection with Shope fibroma virus DNA.

Authors:  K M Obom; B G Pogo
Journal:  Virus Genes       Date:  1989-09       Impact factor: 2.332

8.  Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas.

Authors:  V Samuels; J M Barrett; S Bockman; C G Pantazis; M B Allen
Journal:  Am J Pathol       Date:  1989-04       Impact factor: 4.307

9.  Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.

Authors:  K Yoshida; H Kuniyasu; W Yasui; Y Kitadai; T Toge; E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

10.  Expression of antisense epidermal growth factor receptor RNA downmodulates the malignant behavior of human colon cancer cells.

Authors:  S Chakrabarty; S Rajagopal; S Huang
Journal:  Clin Exp Metastasis       Date:  1995-05       Impact factor: 5.150
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