OBJECTIVES: To investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis. MATERIALS AND METHODS:Seventy-five patients and 20 healthy volunteers were enrolled in this study. Renal function and kidney biopsies were evaluated. For DTI, a respiratory-triggered coronal EPI sequence was performed (TR, 1400 ms; TE, 76 ms; diffusion direction, 6; NEX, 4; b values, 0 and 600 s/mm2; slices thickness, 6 mm, with no intersection gap). Renal ADC and FA values were calculated and compared between the groups. Correlations between ADC/FA and histopathology were evaluated. RESULTS:ADC values decreased with increased stages. ADC differences in renal parenchyma at different disease stages were found, with the exception of the control group compared with stage 1 patients; similar results were obtained for FA. ADC values in the cortex and medulla in stage 1-3 patients were both statistically different, similar to the FA values. A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex (r = -0.74), similar to the degree of tubulointerstitial fibrosis with FA in the medulla (r = -0.76). CONCLUSIONS:ADC and FA values are correlated with the degree of renal impairment, the percentage of glomerulosclerosis, and area of interstitial fibrosis. KEY POINTS: • DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis. • ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis. • Identification of renal impairment is helpful for timely treatment. • DTI can be used for non-invasive assessment of renal pathology.
RCT Entities:
OBJECTIVES: To investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis. MATERIALS AND METHODS: Seventy-five patients and 20 healthy volunteers were enrolled in this study. Renal function and kidney biopsies were evaluated. For DTI, a respiratory-triggered coronal EPI sequence was performed (TR, 1400 ms; TE, 76 ms; diffusion direction, 6; NEX, 4; b values, 0 and 600 s/mm2; slices thickness, 6 mm, with no intersection gap). Renal ADC and FA values were calculated and compared between the groups. Correlations between ADC/FA and histopathology were evaluated. RESULTS: ADC values decreased with increased stages. ADC differences in renal parenchyma at different disease stages were found, with the exception of the control group compared with stage 1 patients; similar results were obtained for FA. ADC values in the cortex and medulla in stage 1-3 patients were both statistically different, similar to the FA values. A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex (r = -0.74), similar to the degree of tubulointerstitial fibrosis with FA in the medulla (r = -0.76). CONCLUSIONS: ADC and FA values are correlated with the degree of renal impairment, the percentage of glomerulosclerosis, and area of interstitial fibrosis. KEY POINTS: • DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis. • ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis. • Identification of renal impairment is helpful for timely treatment. • DTI can be used for non-invasive assessment of renal pathology.
Authors: Mike Notohamiprodjo; Olaf Dietrich; Wihelm Horger; Annie Horng; Andreas D Helck; Karin A Herrmann; Maximilian F Reiser; Christian Glaser Journal: Invest Radiol Date: 2010-05 Impact factor: 6.016
Authors: Lorenzo Mannelli; Massimo Valentino; Giacomo Laffi; David J Lomas; Eric E Sigmund; Eytan Raz; Hersh Chandarana Journal: G Ital Nefrol Date: 2010 Nov-Dec
Authors: Ia Iu Proletov; E S Saganova; O V Galkina; I M Zubina; E O Bogdanova; V G Sipovskiĭ; A V Smirnov Journal: Ter Arkh Date: 2013 Impact factor: 0.467
Authors: Mike Notohamiprodjo; Christian Glaser; Karin A Herrmann; Olaf Dietrich; Ulrike I Attenberger; Maximilian F Reiser; Stefan O Schoenberg; Henrik J Michaely Journal: Invest Radiol Date: 2008-10 Impact factor: 6.016
Authors: I M E Desar; E G W ter Voert; Th Hambrock; J J A van Asten; D J van Spronsen; P F A Mulders; A Heerschap; W T A van der Graaf; H W M van Laarhoven; C M L van Herpen Journal: Cancer Imaging Date: 2012-01-12 Impact factor: 3.909
Authors: Feng Wang; Daisuke Katagiri; Ke Li; Keiko Takahashi; Suwan Wang; Shinya Nagasaka; Hua Li; C Chad Quarles; Ming-Zhi Zhang; Akira Shimizu; John C Gore; Raymond C Harris; Takamune Takahashi Journal: Magn Reson Med Date: 2018-05-30 Impact factor: 4.668
Authors: B F Kjølby; A R Khan; A Chuhutin; L Pedersen; J B Jensen; S Jakobsen; D Zeidler; R Sangill; J R Nyengaard; S N Jespersen; B Hansen Journal: NMR Biomed Date: 2016-10-12 Impact factor: 4.044
Authors: Feng Wang; Suwan Wang; Yahua Zhang; Ke Li; Raymond C Harris; John C Gore; Ming-Zhi Zhang Journal: NMR Biomed Date: 2019-07-29 Impact factor: 4.044
Authors: Feng Wang; Daniel C Colvin; Suwan Wang; Hua Li; Zhongliang Zu; Raymond C Harris; Ming-Zhi Zhang; John C Gore Journal: Magn Reson Med Date: 2020-03-06 Impact factor: 4.668