Wen-jun Fan1,2, Tao Ren1, Qiong Li1, Pan-li Zuo3, Miao-miao Long1, Chun-bai Mo4, Li-hua Chen1, Li-xiang Huang1, Wen Shen5. 1. Department of Radiology, Tianjin Medical University First Central Hospital, Tianjin, 300192, China. 2. Medical Department, Armed Police Corps Hospital of Henan Province, Zhengzhou, 450052, China. 3. Siemens Healthcare, MR Collaboration NE Asia, Beijing, 100102, China. 4. Department of Transplantation Surgery, Tianjin First Central Hospital, Tianjin, 300192, China. 5. Department of Radiology, Tianjin Medical University First Central Hospital, Tianjin, 300192, China. shenwen66happy@163.com.
Abstract
OBJECTIVES: To investigate the value of diffusion tensor imaging (DTI) and tractography in renal allografts at the early stage after kidney transplantation. METHODS: This study was approved by the institutional ethical review committee, and written informed consent was obtained. A total of 54 renal allograft recipients 2-3 weeks after transplantation and 26 age-matched healthy volunteers underwent renal DTI with a 3.0-T magnetic resonance imaging (MRI) system. Recipients were divided into three groups according to the estimated glomerular filtration rate (eGFR). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the cortex and medulla were measured and compared among the groups. Whole-kidney tractography was performed. Correlation of eGFR with diffusion parameters was evaluated. RESULTS: In allografts with stable function, the medullary ADC was higher and the cortical FA was lower (p < 0.001) than in healthy kidneys. The cortical ADC, medullary ADC and FA decreased as the allograft function declined, and with a positive correlation with eGFR (p < 0.001); cortical FA did not. Tractography demonstrated a decrease of tract density in impaired functional allografts. CONCLUSIONS: Renal DTI produces reliable results to assess renal allograft function at the early stage after transplantation. KEY POINTS: • DTI and tractography can evaluate renal allograft function at an early stage • Medullary FA, cortical and medullary ADC can effectively evaluate allograft function • Medullary FA, cortical and medullary ADC are correlated with eGFR in renal allografts • Medullary ADC increased and cortical FA decreased in stable allografts compared to control subjects • Medullary FA, cortical and medullary ADC decreased and allograft function declined.
OBJECTIVES: To investigate the value of diffusion tensor imaging (DTI) and tractography in renal allografts at the early stage after kidney transplantation. METHODS: This study was approved by the institutional ethical review committee, and written informed consent was obtained. A total of 54 renal allograft recipients 2-3 weeks after transplantation and 26 age-matched healthy volunteers underwent renal DTI with a 3.0-T magnetic resonance imaging (MRI) system. Recipients were divided into three groups according to the estimated glomerular filtration rate (eGFR). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the cortex and medulla were measured and compared among the groups. Whole-kidney tractography was performed. Correlation of eGFR with diffusion parameters was evaluated. RESULTS: In allografts with stable function, the medullary ADC was higher and the cortical FA was lower (p < 0.001) than in healthy kidneys. The cortical ADC, medullary ADC and FA decreased as the allograft function declined, and with a positive correlation with eGFR (p < 0.001); cortical FA did not. Tractography demonstrated a decrease of tract density in impaired functional allografts. CONCLUSIONS: Renal DTI produces reliable results to assess renal allograft function at the early stage after transplantation. KEY POINTS: • DTI and tractography can evaluate renal allograft function at an early stage • Medullary FA, cortical and medullary ADC can effectively evaluate allograft function • Medullary FA, cortical and medullary ADC are correlated with eGFR in renal allografts • Medullary ADC increased and cortical FA decreased in stable allografts compared to control subjects • Medullary FA, cortical and medullary ADC decreased and allograft function declined.
Authors: Wen Qin; Chun Shui Yu; Fan Zhang; Xiang Ying Du; Heng Jiang; Yu Xia Yan; Kun Cheng Li Journal: Magn Reson Med Date: 2009-04 Impact factor: 4.668
Authors: Mike Notohamiprodjo; Hersh Chandarana; Artem Mikheev; Henry Rusinek; John Grinstead; Thorsten Feiweier; José G Raya; Vivian S Lee; Eric E Sigmund Journal: Magn Reson Med Date: 2014-04-21 Impact factor: 4.668
Authors: Mike Notohamiprodjo; Christian Glaser; Karin A Herrmann; Olaf Dietrich; Ulrike I Attenberger; Maximilian F Reiser; Stefan O Schoenberg; Henrik J Michaely Journal: Invest Radiol Date: 2008-10 Impact factor: 6.016
Authors: Stan Benjamens; Andor W J M Glaudemans; Stefan P Berger; Riemer H J A Slart; Robert A Pol Journal: Eur Radiol Date: 2018-03-07 Impact factor: 5.315
Authors: Long Jiang Zhang; Jin Peng; Jiqiu Wen; U Joseph Schoepf; Akos Varga-Szemes; L Parkwood Griffith; Yuan Meng Yu; Shu Min Tao; Yan Jun Li; Xue Feng Ni; Jian Xu; Dong Hong Shi; Guang Ming Lu Journal: Eur Radiol Date: 2018-04-17 Impact factor: 5.315
Authors: Mick J M van Eijs; Arjan D van Zuilen; Anneloes de Boer; Martijn Froeling; Tri Q Nguyen; Jaap A Joles; Tim Leiner; Marianne C Verhaar Journal: Front Physiol Date: 2017-05-16 Impact factor: 4.566