Literature DB >> 24760469

The comparison of fluid dynamics parameters in an Andersen cascade impactor equipped with and without a preseparator.

Janwit Dechraksa1, Tan Suwandecha, Kittinan Maliwan, Teerapol Srichana.   

Abstract

The fluid dynamic data in Andersen cascade impactor (ACI) are still lacking. Airflows and those affected parameters can be predicted in a preseparator and Andersen cascade impactor (ACI) by computational modeling. This study developed a validated computational fluid dynamic (CFD) model of an ACI and investigated the effects of the preseparator on the CFD parameters. Validation of the computational nozzle velocity for each of the stage 0 to stage 5 of the ACI stages was found to be within a 3.56% error. The flow field indicated that the preseparator accelerated the airflow velocity at the induction tube from 1.13 to 3.71 ± 0.09 m/s and 2.40 to 8.68 ± 0.16 m/s (at 28.3 and 60 L/min of flow rate, respectively). The preseparator produced a nozzle's wall shear stress ranged from 0.08 to 0.34 Pa on a collection plate, while the ex-preseparator spread wall shear from the plate's center was in a range of 0.11 to 0.37 Pa (at 28.3 L/min of flow rate). Moreover, the nozzle velocities increased along the distance from the middle of the collection plate to the periphery. The CFD explained the airflow of the preseparator equipped model by accelerating the airflow along the inlet port to maximize the trapping of desirable particles and the generation of a smooth wall shear stress at the collection plate to reduce the particle re-entrainment. While, the ex-preseparator generated an airflow that resulted in a higher wall shear stress occurring on the lower stages.

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Year:  2014        PMID: 24760469      PMCID: PMC4037481          DOI: 10.1208/s12249-014-0102-2

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN: 1530-9932            Impact factor:   3.246


  8 in total

1.  Evaluation of preseparator performance for the 8-stage nonviable andersen impactor.

Authors:  V V Sethuraman; A J Hickey
Journal:  AAPS PharmSciTech       Date:  2001-03-26       Impact factor: 3.246

2.  Dry powder inhaler device influence on carrier particle performance.

Authors:  Martin J Donovan; Sin Hyen Kim; Venkatramanan Raman; Hugh D Smyth
Journal:  J Pharm Sci       Date:  2011-11-17       Impact factor: 3.534

3.  Effect of device design on the in vitro performance and comparability for capsule-based dry powder inhalers.

Authors:  Jagdeep Shur; Sau Lee; Wallace Adams; Robert Lionberger; James Tibbatts; Robert Price
Journal:  AAPS J       Date:  2012-06-22       Impact factor: 4.009

4.  Comparison of delivery characteristics from a combination metered-dose inhaler using the Andersen cascade impactor and the next generation pharmaceutical impactor.

Authors:  Changning Guo; Stacey R Gillespie; John Kauffman; William H Doub
Journal:  J Pharm Sci       Date:  2008-08       Impact factor: 3.534

5.  Numerical calibration of the Andersen cascade impactor using a single jet model.

Authors:  Yuriy Gulak; Eric Jayjock; Fernando Muzzio; Andrea Bauer; Paul McGlynn
Journal:  Int J Pharm       Date:  2009-05-21       Impact factor: 5.875

6.  Cascade impactor practice for a high dose dry powder inhaler at 90 L/min: NGI versus modified 6-stage and 8-stage ACI.

Authors:  Akihiko Kamiya; Masahiro Sakagami; Peter R Byron
Journal:  J Pharm Sci       Date:  2009-03       Impact factor: 3.534

7.  Aerodynamic characteristics of a dry powder inhaler at low inhalation flows using a mixing inlet with an Andersen Cascade Impactor.

Authors:  Dinesh Kumar Nadarassan; Khaled H Assi; Henry Chrystyn
Journal:  Eur J Pharm Sci       Date:  2010-01-20       Impact factor: 4.384

8.  Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines.

Authors:  William Wong; John Crapper; Hak-Kim Chan; Daniela Traini; Paul M Young
Journal:  J Pharm Biomed Anal       Date:  2009-10-29       Impact factor: 3.935

  8 in total
  2 in total

1.  Deposition Pattern of Polydisperse Dry Powders in Andersen Cascade Impactor - Aerodynamic Assessment for Inhalation Experimentally and In Silico.

Authors:  Janwit Dechraksa; Tan Suwandecha; Teerapol Srichana
Journal:  Turk J Pharm Sci       Date:  2020-02-19

Review 2.  Nanoparticle Delivery Platforms for RNAi Therapeutics Targeting COVID-19 Disease in the Respiratory Tract.

Authors:  Yuan Zhang; Juhura G Almazi; Hui Xin Ong; Matt D Johansen; Scott Ledger; Daniela Traini; Philip M Hansbro; Anthony D Kelleher; Chantelle L Ahlenstiel
Journal:  Int J Mol Sci       Date:  2022-02-22       Impact factor: 5.923

  2 in total

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