Literature DB >> 14727889

Evaluation of preseparator performance for the 8-stage nonviable andersen impactor.

V V Sethuraman1, A J Hickey.   

Abstract

The preseparator of an Andersen impactor with different coating treatments for a range of particle-size distributions was evaluated. Limited theoretical simulations constrained by simplifying assumptions of the airflow fields in the preseparator and upper stages of an 8-stage Andersen impactor were used to reveal low-velocity and high-pressure regions for potential deposition. These regions were then sampled in subsequent particle deposition experiments. Disodium fluorescein aerosols were sampled with different coating treatments of the preseparator floor. Particles collected at impactor stages determined particle size distributions. Stage deposition was compared between different preseparator treatments (buffer and silicon oil). Collection efficiency in the preseparator followed the pattern buffer > silicon oil > untreated. Statistical differences (P < 0.05) were noted in collection efficiency of large particles (45 micro m-75 microm) in the preseparator. The mass median aerodynamic diameters and geometric standard deviations showed some statistical differences when different preseparator treatments for large particles were used; therefore, preseparator coating was shown to influence performance and thereby estimates of particle size by inertial impaction.

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Year:  2001        PMID: 14727889      PMCID: PMC2750258          DOI: 10.1208/pt020104

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN: 1530-9932            Impact factor:   3.246


  2 in total

1.  Can in vitro particle size measurements be used to predict pulmonary deposition of aerosol from inhalers?

Authors:  C G Thiel
Journal:  J Aerosol Med       Date:  1998

2.  Preparation and characterization of disodium fluorescein powders in association with lauric and capric acids.

Authors:  A J Hickey; G V Jackson; F J Fildes
Journal:  J Pharm Sci       Date:  1988-09       Impact factor: 3.534

  2 in total
  3 in total

1.  Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated andersen cascade impactors (ACIs): part 2--investigation of bias in extra-fine mass fraction with AIM-HRT impactor.

Authors:  Jolyon P Mitchell; Mark W Nagel; Cathy C Doyle; Rubina S Ali; Valentina I Avvakoumova; J David Christopher; Jorge Quiroz; Helen Strickland; Terrence Tougas; Svetlana Lyapustina
Journal:  AAPS PharmSciTech       Date:  2010-07-10       Impact factor: 3.246

2.  Good Cascade Impactor Practice (GCIP) and considerations for "in-use" specifications.

Authors:  S C Nichols; J P Mitchell; C M Shelton; D L Roberts
Journal:  AAPS PharmSciTech       Date:  2013-01-24       Impact factor: 3.246

3.  The comparison of fluid dynamics parameters in an Andersen cascade impactor equipped with and without a preseparator.

Authors:  Janwit Dechraksa; Tan Suwandecha; Kittinan Maliwan; Teerapol Srichana
Journal:  AAPS PharmSciTech       Date:  2014-04-24       Impact factor: 3.246

  3 in total

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