Literature DB >> 24376995

Effect of the bone heterogeneity on the dose prescription in orthovoltage radiotherapy: A Monte Carlo study.

James C L Chow1, Grigor N Grigorov2.   

Abstract

BACKGROUND: In orthovoltage radiotherapy, since the dose prescription at the patient's surface is based on the absolute dose calibration using water phantom, deviation of delivered dose is found as the heterogeneity such as bone present under the patient's surface. AIM: This study investigated the dosimetric impact due to the bone heterogeneity on the surface dose in orthovoltage radiotherapy.
MATERIALS AND METHODS: A 220 kVp photon beam with field size of 5 cm diameter, produced by a Gulmay D3225 orthovoltage X-ray machine was modeled by the BEAMnrc. Phantom containing water (thickness = 1-5 mm) on top of a bone (thickness = 1 cm) was irradiated by the 220 kVp photon beam. Percentage depth dose (PDD), surface dose and photon energy spectrum were determined using Monte Carlo simulations (the BEAMnrc code).
RESULTS: PDD results showed that the maximum bone dose was about 210% higher than the surface dose in the phantoms with different thicknesses of water. Surface dose was found to be increased in the range of 2.5-3.7%, when the distance between the phantom surface and bone was increased in the range of 1-5 mm. The increase of surface dose was found not to follow the increase of water thickness, and the maximum increase of surface dose was found at the thickness of water equal to 3 mm.
CONCLUSIONS: For the accepted total orthovoltage radiation treatment uncertainty of 5%, a neglected consideration of the bone heterogeneity during the dose prescription in the sites of forehead, chest wall and kneecap with soft tissue thickness = 1-5 mm would cause more than two times of the bone dose, and contribute an uncertainty of about 2.5-3.7% to the total uncertainty in the dose delivery.

Entities:  

Keywords:  Bone backscatter and surface dose; Monte Carlo simulation; Orthovoltage photon beam; Orthovoltage radiation therapy

Year:  2011        PMID: 24376995      PMCID: PMC3863236          DOI: 10.1016/j.rpor.2011.09.001

Source DB:  PubMed          Journal:  Rep Pract Oncol Radiother        ISSN: 1507-1367


  12 in total

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Authors:  C M Ma; C W Coffey; L A DeWerd; C Liu; R Nath; S M Seltzer; J P Seuntjens
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Authors:  Ernesto Mainegra-Hing; D W O Rogers; Iwan Kawrakow
Journal:  Med Phys       Date:  2005-03       Impact factor: 4.071

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Journal:  Med Phys       Date:  1995-05       Impact factor: 4.071

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Journal:  Med Phys       Date:  1997-11       Impact factor: 4.071

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Journal:  Phys Med Biol       Date:  1997-12       Impact factor: 3.609

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Authors:  E C McCullough
Journal:  Int J Radiat Oncol Biol Phys       Date:  1990-05       Impact factor: 7.038

8.  Backscatter dose perturbation in kilovoltage photon beams at high atomic number interfaces.

Authors:  I J Das; K L Chopra
Journal:  Med Phys       Date:  1995-06       Impact factor: 4.071

9.  Radiation therapy for skin cancer near the eye: kilovoltage x-rays versus electrons.

Authors:  R J Amdur; K J Kalbaugh; L M Ewald; J T Parsons; W M Mendenhall; F J Bova; R R Million
Journal:  Int J Radiat Oncol Biol Phys       Date:  1992       Impact factor: 7.038

10.  Large efficiency improvements in BEAMnrc using directional bremsstrahlung splitting.

Authors:  I Kawrakow; D W O Rogers; B R B Walters
Journal:  Med Phys       Date:  2004-10       Impact factor: 4.071

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  1 in total

1.  Radiation dose enhancement in skin therapy with nanoparticle addition: A Monte Carlo study on kilovoltage photon and megavoltage electron beams.

Authors:  Xiao J Zheng; James C L Chow
Journal:  World J Radiol       Date:  2017-02-28
  1 in total

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