Literature DB >> 2429261

Cloning and characterization of a Leishmania gene encoding a RNA spliced leader sequence.

S I Miller, S M Landfear, D F Wirth.   

Abstract

Recent studies on leishmania enriettii tubulin mRNAs revealed a 35 nucleotide addition to their 5' end. The gene that codes for this 35 nucleotide leader sequence has now been cloned and sequenced. In the Leishmania genome, the spliced leader gene exists as a tandem repeat of 438 bases. There are approximately 150 copies of this gene comprising 0.1% of the parasite genome. This gene codes for a 85 nucleotide transcript that contains the spliced leader at its 5' end. The 35 nucleotide sequence and the regions immediately 5' and 3' to it are highly conserved across trypanosomatids. We have detected a RNA molecule that is a putative by-product of the processing reaction in which the 35 nucleotide spliced leader has been transferred to mRNA. We suggest that this molecule is the remnant of the spliced leader transcript after removal of the 35 nucleotide spliced leader.

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Year:  1986        PMID： 2429261      PMCID： PMC311755          DOI： 10.1093/nar/14.18.7341

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  25 in total

Review 1.  The role of RNA priming in viral and trypanosomal mRNA synthesis.

Authors:  R M Krug
Journal:  Cell       Date:  1985-07       Impact factor: 41.582

2.  Calmodulin genes in trypanosomes are tandemly repeated and produce multiple mRNAs with a common 5' leader sequence.

Authors:  C Tschudi; A S Young; L Ruben; C L Patton; F F Richards
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

3.  Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro.

Authors:  B Ruskin; A R Krainer; T Maniatis; M R Green
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

4.  Structure of mRNA encoded by tubulin genes in Leishmania enriettii.

Authors:  S M Landfear; D F Wirth
Journal:  Mol Biochem Parasitol       Date:  1985-04       Impact factor: 1.759

5.  Control of tubulin gene expression in the parasitic protozoan Leishmania enriettii.

Authors:  S M Landfear; D F Wirth
Journal:  Nature       Date:  1984 Jun 21-27       Impact factor: 49.962

6.  Chromosome rearrangements in Trypanosoma brucei.

Authors:  L H Van der Ploeg; A W Cornelissen; P A Michels; P Borst
Journal:  Cell       Date:  1984-11       Impact factor: 41.582

7.  Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes.

Authors:  D A Campbell; D A Thornton; J C Boothroyd
Journal:  Nature       Date:  1984 Sep 27-Oct 3       Impact factor: 49.962

8.  Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species.

Authors:  T De Lange; T M Berkvens; H J Veerman; A C Frasch; J D Barry; P Borst
Journal:  Nucleic Acids Res       Date:  1984-06-11       Impact factor: 16.971

9.  Discontinuous synthesis of mRNA in trypanosomes.

Authors:  J M Kooter; T De Lange; P Borst
Journal:  EMBO J       Date:  1984-10       Impact factor: 11.598

10.  Identification of a small RNA containing the trypanosome spliced leader: a donor of shared 5' sequences of trypanosomatid mRNAs?

Authors:  M Milhausen; R G Nelson; S Sather; M Selkirk; N Agabian
Journal:  Cell       Date:  1984-10       Impact factor: 41.582
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  42 in total

1.  Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major.

Authors:  G M Kapler; K Zhang; S M Beverley
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

Review 2.  mRNA processing in the Trypanosomatidae.

Authors:  K Perry; N Agabian
Journal:  Experientia       Date:  1991-02-15

3.  Nucleotide sequence of the spliced leader RNA gene from Leishmania mexicana amazonensis.

Authors:  R Agami; M Shapira
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

4.  Structural isoforms of a membrane transport protein from Leishmania enriettii.

Authors:  S P Stack; D A Stein; S M Landfear
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

5.  Nucleotide sequence of the Leishmania donovani medRNA gene.

Authors:  K Wilson; S Hanson; S Landfear; B Ullman
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

6.  A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.

Authors:  W S Pulkkinen; S I Miller
Journal:  J Bacteriol       Date:  1991-01       Impact factor: 3.490

7.  Convergent origins and rapid evolution of spliced leader trans-splicing in metazoa: insights from the ctenophora and hydrozoa.

Authors:  Romain Derelle; Tsuyoshi Momose; Michael Manuel; Corinne Da Silva; Patrick Wincker; Evelyn Houliston
Journal:  RNA       Date:  2010-02-08       Impact factor: 4.942

8.  A physical map of the Leishmania major Friedlin genome.

Authors:  A C Ivens; S M Lewis; A Bagherzadeh; L Zhang; H M Chan; D F Smith
Journal:  Genome Res       Date:  1998-02       Impact factor: 9.043

9.  The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.

Authors:  R E Sutton; J C Boothroyd
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

Review 10.  On the Possibility of an Early Evolutionary Origin for the Spliced Leader Trans-Splicing.

Authors:  Zuzana Krchňáková; Juraj Krajčovič; Matej Vesteg
Journal:  J Mol Evol       Date:  2017-07-25       Impact factor: 2.395
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