Literature DB >> 3336365

The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.

R E Sutton1, J C Boothroyd.   

Abstract

Most, if not all, trypanosome mRNAs have the same 35-base sequence at their 5' terminus which is derived from a short RNA (medRNA) probably by the process of trans-splicing. It is of interest, evolutionarily and mechanistically, to determine the chemical structure of the 5' terminus of the precursor (medRNA) and product (mRNA). We demonstrate here that the cap structure of both is most probably 7-methylguanosine in a 5',5' triphosphate linkage, consistent with a precursor/product relationship.

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Year:  1988        PMID： 3336365      PMCID： PMC363158          DOI： 10.1128/mcb.8.1.494-496.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  27 in total

1.  Purification of messenger RNA and heterogeneous nuclear RNA containing poly(a) sequences.

Authors:  H Nakazato; M Edmonds
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

2.  The chromatography of RNA and oligoribonucleotides on boronate-substituted agarose and polyacrylamide.

Authors:  B Pace; N R Pace
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

3.  SnRNAs, SnRNPs, and RNA processing.

Authors:  H Busch; R Reddy; L Rothblum; Y C Choi
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

4.  Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription?

Authors:  T De Lange; A Y Liu; L H Van der Ploeg; P Borst; M C Tromp; J H Van Boom
Journal:  Cell       Date:  1983-10       Impact factor: 41.582

5.  Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication.

Authors:  R Brun
Journal:  Acta Trop       Date:  1979-09       Impact factor: 3.112

Review 6.  5'-terminal cap structure in eucaryotic messenger ribonucleic acids.

Authors:  A K Banerjee
Journal:  Microbiol Rev       Date:  1980-06

7.  Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5' end.

Authors:  J C Boothroyd; G A Cross
Journal:  Gene       Date:  1982-12       Impact factor: 3.688

8.  Yeast contains small nuclear RNAs encoded by single copy genes.

Authors:  J A Wise; D Tollervey; D Maloney; H Swerdlow; E J Dunn; C Guthrie
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

9.  Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei.

Authors:  R G Nelson; M Parsons; P J Barr; K Stuart; M Selkirk; N Agabian
Journal:  Cell       Date:  1983-10       Impact factor: 41.582

10.  Evidence for trans splicing in trypanosomes.

Authors:  R E Sutton; J C Boothroyd
Journal:  Cell       Date:  1986-11-21       Impact factor: 41.582
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  11 in total

1.  Characterization of VSG gene expression site promoters and promoter-associated DNA rearrangement events.

Authors:  K Gottesdiener; H M Chung; S D Brown; M G Lee; L H Van der Ploeg
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

2.  In vitro capping in Trypanosoma cruzi identifies and shows specificity for the spliced leader RNA and U-RNAs.

Authors:  T A Zwierzynski; G A Buck
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971

3.  Permeable trypanosome cells as a model system for transcription and trans-splicing.

Authors:  E Ullu; C Tschudi
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971

4.  A 5' exo-ribonuclease and RNA ligase of T. brucei.

Authors:  J Huang; L H Van der Ploeg
Journal:  Nucleic Acids Res       Date:  1988-10-25       Impact factor: 16.971

5.  Polycistronic transcripts in trypanosomes and their accumulation during heat shock: evidence for a precursor role in mRNA synthesis.

Authors:  M L Muhich; J C Boothroyd
Journal:  Mol Cell Biol       Date:  1988-09       Impact factor: 4.272

6.  A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.

Authors:  A Rajkovic; R E Davis; J N Simonsen; F M Rottman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

7.  trans-spliced Caenorhabditis elegans mRNAs retain trimethylguanosine caps.

Authors:  R F Liou; T Blumenthal
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

8.  The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei.

Authors:  Roya Zoraghi; Thomas Seebeck
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-02       Impact factor: 11.205

9.  Analysis of small nuclear ribonucleoproteins (RNPs) in Trypanosoma brucei: structural organization and protein components of the spliced leader RNP.

Authors:  M Cross; A Günzl; Z Palfi; A Bindereif
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

10.  RNA-protein complexes mediate in vitro capping of the spliced-leader primary transcript and U-RNAs in Trypanosoma cruzi.

Authors:  T A Zwierzynski; G A Buck
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205
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