Literature DB >> 24262893

The National Institutes of Health's Biomedical Translational Research Information System (BTRIS): design, contents, functionality and experience to date.

James J Cimino1, Elaine J Ayres2, Lyubov Remennik2, Sachi Rath3, Robert Freedman3, Andrea Beri3, Yang Chen3, Vojtech Huser2.   

Abstract

The US National Institutes of Health (NIH) has developed the Biomedical Translational Research Information System (BTRIS) to support researchers' access to translational and clinical data. BTRIS includes a data repository, a set of programs for loading data from NIH electronic health records and research data management systems, an ontology for coding the disparate data with a single terminology, and a set of user interface tools that provide access to identified data from individual research studies and data across all studies from which individually identifiable data have been removed. This paper reports on unique design elements of the system, progress to date and user experience after five years of development and operation. Published by Elsevier Inc.

Entities:  

Keywords:  Clinical research; Ontology; Research data repository; Research data warehouse; Translational research

Mesh：

Year:  2013        PMID： 24262893      PMCID： PMC4026354          DOI： 10.1016/j.jbi.2013.11.004

Source DB:  PubMed          Journal:  J Biomed Inform        ISSN： 1532-0464            Impact factor:   6.317


  34 in total

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3.  The NCBI dbGaP database of genotypes and phenotypes.

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Journal:  Nat Genet       Date:  2007-10       Impact factor: 38.330

4.  An electronic practice-based network for observational comparative effectiveness research.

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5.  QAV: querying entity-attribute-value metadata in a biomedical database.

Authors:  P M Nadkarni
Journal:  Comput Methods Programs Biomed       Date:  1997-06       Impact factor: 5.428

6.  The false security of blind dates: chrononymization's lack of impact on data privacy of laboratory data.

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Journal:  Appl Clin Inform       Date:  2012-10-24       Impact factor: 2.342

7.  The ClinicalTrials.gov results database--update and key issues.

Authors:  Deborah A Zarin; Tony Tse; Rebecca J Williams; Robert M Califf; Nicholas C Ide
Journal:  N Engl J Med       Date:  2011-03-03       Impact factor: 91.245

8.  Building a virtual cancer research organization.

Authors:  Mark C Hornbrook; Gene Hart; Jennifer L Ellis; Donald J Bachman; Gary Ansell; Sarah M Greene; Edward H Wagner; Roy Pardee; Mark M Schmidt; Ann Geiger; Amy L Butani; Terry Field; Hassan Fouayzi; Irina Miroshnik; Liyan Liu; Robert Diseker; Karen Wells; Rick Krajenta; Lois Lamerato; Christine Neslund Dudas
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Review 9.  Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs.

Authors:  Elmer V Bernstam; William R Hersh; Stephen B Johnson; Christopher G Chute; Hien Nguyen; Ida Sim; Meredith Nahm; Mark G Weiner; Perry Miller; Robert P DiLaura; Marc Overcash; Harold P Lehmann; David Eichmann; Brian D Athey; Richard H Scheuermann; Nick Anderson; Justin Starren; Paul A Harris; Jack W Smith; Ed Barbour; Jonathan C Silverstein; David A Krusch; Rakesh Nagarajan; Michael J Becich
Journal:  Acad Med       Date:  2009-07       Impact factor: 6.893

10.  In defense of the Desiderata.

Authors:  James J Cimino
Journal:  J Biomed Inform       Date:  2005-12-09       Impact factor: 6.317
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  17 in total

Review 1.  Review and evaluation of electronic health records-driven phenotype algorithm authoring tools for clinical and translational research.

Authors:  Jie Xu; Luke V Rasmussen; Pamela L Shaw; Guoqian Jiang; Richard C Kiefer; Huan Mo; Jennifer A Pacheco; Peter Speltz; Qian Zhu; Joshua C Denny; Jyotishman Pathak; William K Thompson; Enid Montague
Journal:  J Am Med Inform Assoc       Date:  2015-07-29       Impact factor: 4.497

2.  Clinical Research Informatics: Recent Advances and Future Directions.

Authors:  M Dugas
Journal:  Yearb Med Inform       Date:  2015-08-13

3.  How healthy are the "Healthy volunteers"? Penetrance of NAFLD in the biomedical research volunteer pool.

Authors:  Varun Takyar; Anand Nath; Andrea Beri; Ahmed M Gharib; Yaron Rotman
Journal:  Hepatology       Date:  2017-07-27       Impact factor: 17.425

4.  Adapting a Clinical Data Repository to ICD-10-CM through the use of a Terminology Repository.

Authors:  James J Cimino; Lyubov Remennick
Journal:  AMIA Annu Symp Proc       Date:  2014-11-14

5.  Design and Implementation of a Secure Computing Environment for Analysis of Sensitive Data at an Academic Medical Center.

Authors:  Peter R Oxley; John Ruffing; Thomas R Campion; Terrie R Wheeler; Curtis L Cole
Journal:  AMIA Annu Symp Proc       Date:  2018-12-05

6.  Classifying Clinical Trial Eligibility Criteria to Facilitate Phased Cohort Identification Using Clinical Data Repositories.

Authors:  Amy Y Wang; William J Lancaster; Matthew C Wyatt; Luke V Rasmussen; Daniel G Fort; James J Cimino
Journal:  AMIA Annu Symp Proc       Date:  2018-04-16

7.  Standardizing data exchange for clinical research protocols and case report forms: An assessment of the suitability of the Clinical Data Interchange Standards Consortium (CDISC) Operational Data Model (ODM).

Authors:  Vojtech Huser; Chandan Sastry; Matthew Breymaier; Asma Idriss; James J Cimino
Journal:  J Biomed Inform       Date:  2015-07-15       Impact factor: 6.317

8.  Identifying the Clinical Laboratory Tests from Unspecified "Other Lab Test" Data for Secondary Use.

Authors:  Xuequn Pan; James J Cimino
Journal:  AMIA Annu Symp Proc       Date:  2015-11-05

9.  Evaluating common data models for use with a longitudinal community registry.

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Journal:  J Biomed Inform       Date:  2016-10-29       Impact factor: 6.317

Review 10.  Pharmacogenomics Implementation at the National Institutes of Health Clinical Center.

Authors:  Tristan M Sissung; Jon W McKeeby; Jharana Patel; Juan J Lertora; Parag Kumar; Willy A Flegel; Sharon D Adams; Ellen J Eckes; Frank Mickey; Teri M Plona; Stephanie D Mellot; Ryan N Baugher; Xiaolin Wu; Daniel R Soppet; Mary E Barcus; Vivekananda Datta; Kristen M Pike; Gary DiPatrizio; William D Figg; Barry R Goldspiel
Journal:  J Clin Pharmacol       Date:  2017-10       Impact factor: 3.126
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