| Literature DB >> 24235273 |
Galen D Reed, Cornelius von Morze, Robert Bok, Bertram L Koelsch, Mark Van Criekinge, Kenneth J Smith, Peder E Z Larson, John Kurhanewicz, Daniel B Vigneron.
Abstract
(13)C steady state free precession (SSFP) magnetic resonance imaging and effective spin-spin relaxation time (T2) mapping were performed using hyperpolarized [(13)C] urea and [(13) C,(15)N2] urea injected intravenously in rats. (15)N labeling gave large T2 increases both in solution and in vivo due to the elimination of a strong scalar relaxation pathway. The T2 increase was pronounced in the kidney, with [(13) C,(15) N2] urea giving T2 values of 6.3±1.3 s in the cortex and medulla, and 11±2 s in the renal pelvis. The measured T2 in the aorta was 1.3±0.3 s. [(13)C] urea showed shortened T2 values in the kidney of 0.23±0.03 s compared to 0.28±0.03 s measured in the aorta. The enhanced T2 of [(13)C,(15)N2] urea was utilized to generate large signal enhancement by SSFP acquisitions with flip angles approaching the fully refocused regime. Projection images at 0.94 mm in-plane resolution were acquired with both urea isotopes, with [(13)C,(15) N2] urea giving a greater than four-fold increase in signal-to-noise ratio over [(13)C] urea.Entities:
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Year: 2013 PMID： 24235273 PMCID： PMC4011557 DOI： 10.1109/TMI.2013.2285120
Source DB: PubMed Journal: IEEE Trans Med Imaging ISSN： 0278-0062 Impact factor: 10.048