PURPOSE: Hyperpolarization of carbon-13 ((13) C) nuclei by dissolution dynamic nuclear polarization increases signal-to-noise ratio (SNR) by >10,000-fold for metabolic imaging, but care must be taken when transferring hyperpolarized (HP) samples from polarizer to MR scanner. Some (13) C substrates relax rapidly in low ambient magnetic fields. A handheld electromagnet carrier was designed and constructed to preserve polarization by maintaining a sufficient field during sample transfer. METHODS: The device was constructed with a solenoidal electromagnet, powered by a nonmagnetic battery, holding the HP sample during transfer. A specially designed switch automated deactivation of the field once transfer was complete. Phantom and rat experiments were performed to compare MR signal enhancement with or without the device for HP [(13) C]urea and [1-(13) C]pyruvate. RESULTS: The magnetic field generated by this device was tested to be >50 G over a 6-cm central section. In phantom and rat experiments, [(13) C]urea transported via the device showed SNR improvement by a factor of 1.8-1.9 over samples transferred through the background field. CONCLUSION: A device was designed and built to provide a suitably high yet safe magnetic field to preserve hyperpolarization during sample transfer. Comparative testing demonstrated SNR improvements of approximately two-fold for [(13) C]urea while maintaining SNR for [1-(13) C]pyruvate.
PURPOSE: Hyperpolarization of carbon-13 ((13) C) nuclei by dissolution dynamic nuclear polarization increases signal-to-noise ratio (SNR) by >10,000-fold for metabolic imaging, but care must be taken when transferring hyperpolarized (HP) samples from polarizer to MR scanner. Some (13) C substrates relax rapidly in low ambient magnetic fields. A handheld electromagnet carrier was designed and constructed to preserve polarization by maintaining a sufficient field during sample transfer. METHODS: The device was constructed with a solenoidal electromagnet, powered by a nonmagnetic battery, holding the HP sample during transfer. A specially designed switch automated deactivation of the field once transfer was complete. Phantom and rat experiments were performed to compare MR signal enhancement with or without the device for HP [(13) C]urea and [1-(13) C]pyruvate. RESULTS: The magnetic field generated by this device was tested to be >50 G over a 6-cm central section. In phantom and rat experiments, [(13) C]urea transported via the device showed SNR improvement by a factor of 1.8-1.9 over samples transferred through the background field. CONCLUSION: A device was designed and built to provide a suitably high yet safe magnetic field to preserve hyperpolarization during sample transfer. Comparative testing demonstrated SNR improvements of approximately two-fold for [(13) C]urea while maintaining SNR for [1-(13) C]pyruvate.
Authors: David M Wilson; Kayvan R Keshari; Peder E Z Larson; Albert P Chen; Simon Hu; Mark Van Criekinge; Robert Bok; Sarah J Nelson; Jeffrey M Macdonald; Daniel B Vigneron; John Kurhanewicz Journal: J Magn Reson Date: 2010-04-27 Impact factor: 2.229
Authors: John Kurhanewicz; Daniel B Vigneron; Kevin Brindle; Eduard Y Chekmenev; Arnaud Comment; Charles H Cunningham; Ralph J Deberardinis; Gary G Green; Martin O Leach; Sunder S Rajan; Rahim R Rizi; Brian D Ross; Warren S Warren; Craig R Malloy Journal: Neoplasia Date: 2011-02 Impact factor: 5.715
Authors: Galen D Reed; Cornelius von Morze; Robert Bok; Bertram L Koelsch; Mark Van Criekinge; Kenneth J Smith; Peder E Z Larson; John Kurhanewicz; Daniel B Vigneron Journal: IEEE Trans Med Imaging Date: 2013-10-25 Impact factor: 10.048
Authors: E Johansson; S Månsson; R Wirestam; J Svensson; J S Petersson; K Golman; F Ståhlberg Journal: Magn Reson Med Date: 2004-03 Impact factor: 4.668
Authors: Charles H Cunningham; Albert P Chen; Mark J Albers; John Kurhanewicz; Ralph E Hurd; Yi-Fen Yen; John M Pauly; Sarah J Nelson; Daniel B Vigneron Journal: J Magn Reson Date: 2007-06-02 Impact factor: 2.229
Authors: Enrico Chiavazza; Eugen Kubala; Concetta V Gringeri; Stephan Düwel; Markus Durst; Rolf F Schulte; Marion I Menzel Journal: J Magn Reson Date: 2012-11-29 Impact factor: 2.229
Authors: Sarah J Nelson; John Kurhanewicz; Daniel B Vigneron; Peder E Z Larson; Andrea L Harzstark; Marcus Ferrone; Mark van Criekinge; Jose W Chang; Robert Bok; Ilwoo Park; Galen Reed; Lucas Carvajal; Eric J Small; Pamela Munster; Vivian K Weinberg; Jan Henrik Ardenkjaer-Larsen; Albert P Chen; Ralph E Hurd; Liv-Ingrid Odegardstuen; Fraser J Robb; James Tropp; Jonathan A Murray Journal: Sci Transl Med Date: 2013-08-14 Impact factor: 17.956
Authors: Jason Graham Skinner; Luca Menichetti; Alessandra Flori; Anna Dost; Andreas Benjamin Schmidt; Markus Plaumann; Ferdia Aiden Gallagher; Jan-Bernd Hövener Journal: Mol Imaging Biol Date: 2018-12 Impact factor: 3.488
Authors: Sarmad Siddiqui; Stephen Kadlecek; Mehrdad Pourfathi; Yi Xin; William Mannherz; Hooman Hamedani; Nicholas Drachman; Kai Ruppert; Justin Clapp; Rahim Rizi Journal: Adv Drug Deliv Rev Date: 2016-09-04 Impact factor: 15.470
Authors: Christian Hundshammer; Stephan Düwel; David Ruseckas; Geoffrey Topping; Piotr Dzien; Christoph Müller; Benedikt Feuerecker; Jan B Hövener; Axel Haase; Markus Schwaiger; Steffen J Glaser; Franz Schilling Journal: Sensors (Basel) Date: 2018-02-15 Impact factor: 3.576
Authors: Maximilian Fuetterer; Julia Busch; Sophie M Peereboom; Constantin von Deuster; Lukas Wissmann; Miriam Lipiski; Thea Fleischmann; Nikola Cesarovic; Christian T Stoeck; Sebastian Kozerke Journal: J Cardiovasc Magn Reson Date: 2017-06-21 Impact factor: 5.364
Authors: Cornelius von Morze; John A Engelbach; Galen D Reed; Albert P Chen; James D Quirk; Tyler Blazey; Rohit Mahar; Craig R Malloy; Joel R Garbow; Matthew E Merritt Journal: Magn Reson Med Date: 2020-11-12 Impact factor: 4.668