Literature DB >> 24204016

FutureTox: building the road for 21st century toxicology and risk assessment practices.

J Craig Rowlands1, Miriam Sander, James S Bus.   

Abstract

This article reports on the outcome of FutureTox, a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) workshop, whose goal was to address the challenges and opportunities associated with implementing 21st century technologies for toxicity testing, hazard identification, and risk assessment. One goal of the workshop was to facilitate an interactive multisector and discipline dialog. To this end, workshop invitees and participants included stakeholders from governmental and regulatory agencies, research institutes, academia, and the chemical and pharmaceutical industry in Europe and the United States. The workshop agenda was constructed to collectively review and discuss the state-of-the-science in these fields, better define the problems and challenges, outline their collective goals for the future, and identify areas of common agreement key to advancing these technologies into practice.

Entities:  

Keywords:  in vitro and alternatives; regulatory/policy.; risk assessment

Mesh:

Year:  2013        PMID: 24204016      PMCID: PMC3908722          DOI: 10.1093/toxsci/kft252

Source DB:  PubMed          Journal:  Toxicol Sci        ISSN: 1096-0929            Impact factor:   4.849


  20 in total

1.  Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Authors:  Daniel M Rotroff; Barbara A Wetmore; David J Dix; Stephen S Ferguson; Harvey J Clewell; Keith A Houck; Edward L Lecluyse; Melvin E Andersen; Richard S Judson; Cornelia M Smith; Mark A Sochaski; Robert J Kavlock; Frank Boellmann; Matthew T Martin; David M Reif; John F Wambaugh; Russell S Thomas
Journal:  Toxicol Sci       Date:  2010-07-16       Impact factor: 4.849

2.  Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies.

Authors:  Shakil A Saghir; Alan L Mendrala; Michael J Bartels; Sue J Day; Steve C Hansen; Jacob M Sushynski; James S Bus
Journal:  Toxicol Appl Pharmacol       Date:  2005-07-22       Impact factor: 4.219

3.  Building a model based on scientific consensus for Life Cycle Impact Assessment of chemicals: the search for harmony and parsimony.

Authors:  Michael Z Hauschild; Mark Huijbregts; Olivier Jolliet; Matt MacLeod; Manuele Margni; Dik van de Meent; Ralph K Rosenbaum; Thomas E McKone
Journal:  Environ Sci Technol       Date:  2008-10-01       Impact factor: 9.028

Review 4.  Physicochemical drug properties associated with in vivo toxicological outcomes: a review.

Authors:  David A Price; Julian Blagg; Lyn Jones; Nigel Greene; Travis Wager
Journal:  Expert Opin Drug Metab Toxicol       Date:  2009-08       Impact factor: 4.481

5.  Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.

Authors:  Richard S Judson; Robert J Kavlock; R Woodrow Setzer; Elaine A Cohen Hubal; Matthew T Martin; Thomas B Knudsen; Keith A Houck; Russell S Thomas; Barbara A Wetmore; David J Dix
Journal:  Chem Res Toxicol       Date:  2011-03-08       Impact factor: 3.739

6.  Multimedia modeling of human exposure to chemical substances: the roles of food web biomagnification and biotransformation.

Authors:  Jon A Arnot; Don Mackay; Thomas F Parkerton; Rosemary T Zaleski; Christopher S Warren
Journal:  Environ Toxicol Chem       Date:  2010-01       Impact factor: 3.742

7.  In vitro screening for population variability in chemical toxicity.

Authors:  Shannon H O'Shea; John Schwarz; Oksana Kosyk; Pamela K Ross; Min Jin Ha; Fred A Wright; Ivan Rusyn
Journal:  Toxicol Sci       Date:  2010-10-15       Impact factor: 4.849

8.  Variability of urinary concentrations of polycyclic aromatic hydrocarbon metabolite in general population and comparison of spot, first-morning, and 24-h void sampling.

Authors:  Zheng Li; Lovisa C Romanoff; Michael D Lewin; Erin N Porter; Debra A Trinidad; Larry L Needham; Donald G Patterson; Andreas Sjödin
Journal:  J Expo Sci Environ Epidemiol       Date:  2009-08-26       Impact factor: 5.563

9.  The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.

Authors:  Bas J Blaauboer; Kim Boekelheide; Harvey J Clewell; Mardas Daneshian; Milou M L Dingemans; Alan M Goldberg; Marjoke Heneweer; Joanna Jaworska; Nynke I Kramer; Marcel Leist; Hasso Seibert; Emanuela Testai; Rob J Vandebriel; James D Yager; Joanne Zurlo
Journal:  ALTEX       Date:  2012       Impact factor: 6.043

Review 10.  A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates.

Authors:  Masoud Jamei; Gemma L Dickinson; Amin Rostami-Hodjegan
Journal:  Drug Metab Pharmacokinet       Date:  2009       Impact factor: 3.614

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  12 in total

1.  FutureTox II: in vitro data and in silico models for predictive toxicology.

Authors:  Thomas B Knudsen; Douglas A Keller; Miriam Sander; Edward W Carney; Nancy G Doerrer; David L Eaton; Suzanne Compton Fitzpatrick; Kenneth L Hastings; Donna L Mendrick; Raymond R Tice; Paul B Watkins; Maurice Whelan
Journal:  Toxicol Sci       Date:  2015-02       Impact factor: 4.849

2.  Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing.

Authors:  Raja S Settivari; Nicholas Ball; Lynea Murphy; Reza Rasoulpour; Darrell R Boverhof; Edward W Carney
Journal:  J Am Assoc Lab Anim Sci       Date:  2015-03       Impact factor: 1.232

3.  FutureTox III: Bridges for Translation.

Authors:  Daland R Juberg; Thomas B Knudsen; Miriam Sander; Nancy B Beck; Elaine M Faustman; Donna L Mendrick; John R Fowle; Thomas Hartung; Raymond R Tice; Emmanuel Lemazurier; Richard A Becker; Suzanne Compton Fitzpatrick; George P Daston; Alison Harrill; Ronald N Hines; Douglas A Keller; John C Lipscomb; David Watson; Tina Bahadori; Kevin M Crofton
Journal:  Toxicol Sci       Date:  2016-10-25       Impact factor: 4.849

4.  Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis.

Authors:  Dennis G Thomas; Harish Shankaran; Lisa Truong; Robert L Tanguay; Katrina M Waters
Journal:  Comput Toxicol       Date:  2018-11-10

5.  Programming microphysiological systems for children's health protection.

Authors:  T B Knudsen; B Klieforth; W Slikker
Journal:  Exp Biol Med (Maywood)       Date:  2017-06-28

6.  Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction.

Authors:  Danny Bavli; Sebastian Prill; Elishai Ezra; Gahl Levy; Merav Cohen; Mathieu Vinken; Jan Vanfleteren; Magnus Jaeger; Yaakov Nahmias
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-04       Impact factor: 11.205

Review 7.  FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children.

Authors:  Thomas B Knudsen; Suzanne Compton Fitzpatrick; K Nadira De Abrew; Linda S Birnbaum; Anne Chappelle; George P Daston; Dana C Dolinoy; Alison Elder; Susan Euling; Elaine M Faustman; Kristi Pullen Fedinick; Jill A Franzosa; Derik E Haggard; Laurie Haws; Nicole C Kleinstreuer; Germaine M Buck Louis; Donna L Mendrick; Ruthann Rudel; Katerine S Saili; Thaddeus T Schug; Robyn L Tanguay; Alexandra E Turley; Barbara A Wetmore; Kimberly W White; Todd J Zurlinden
Journal:  Toxicol Sci       Date:  2021-04-12       Impact factor: 4.849

Review 8.  Proteomics for systems toxicology.

Authors:  Bjoern Titz; Ashraf Elamin; Florian Martin; Thomas Schneider; Sophie Dijon; Nikolai V Ivanov; Julia Hoeng; Manuel C Peitsch
Journal:  Comput Struct Biotechnol J       Date:  2014-08-27       Impact factor: 7.271

9.  Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation.

Authors:  Dustin F Kapraun; John F Wambaugh; R Woodrow Setzer; Richard S Judson
Journal:  PLoS One       Date:  2019-05-02       Impact factor: 3.240

10.  Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium.

Authors:  Bettina Maria Fischer; Daniel Neumann; Ann Liza Piberger; Sarah Fremgaard Risnes; Beate Köberle; Andrea Hartwig
Journal:  Arch Toxicol       Date:  2015-11-02       Impact factor: 5.153

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