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Literature DB >> 24038656

Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.

Abstract

Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.

Entities: Chemical

Keywords: MDR; anthracyclines; antitumor agents; metagenomics; natural products

Mesh：

Substances：

Year: 2013 PMID： 24038656 PMCID： PMC3878715 DOI： 10.1002/anie.201305109

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

39 in total

Review 1. Microbial diversity and function in soil: from genes to ecosystems.

Authors: Vigdis Torsvik; Lise Øvreås
Journal: Curr Opin Microbiol Date: 2002-06 Impact factor: 7.934

Review 2. The soil metagenome--a rich resource for the discovery of novel natural products.

Authors: Rolf Daniel
Journal: Curr Opin Biotechnol Date: 2004-06 Impact factor: 9.740

3. Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.

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Journal: Mol Biosyst Date: 2010-05-17

Review 4. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria.

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Journal: FASEB J Date: 1998-03 Impact factor: 5.191

5. Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

Authors: Boojala Vijay B Reddy; Dimitris Kallifidas; Jeffrey H Kim; Zachary Charlop-Powers; Zhiyang Feng; Sean F Brady
Journal: Appl Environ Microbiol Date: 2012-03-16 Impact factor: 4.792

6. Structure-activity relationships of anthracyclines relative to cytotoxicity and effects on macromolecular synthesis in L1210 leukemia cells.

Authors: Y Matsuzawa; T Oki; T Takeuchi; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1981-12 Impact factor: 2.649

Review 7. Role of the sugar moiety in the pharmacological activity of anthracyclines: development of a novel series of disaccharide analogs.

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Journal: Biochem Pharmacol Date: 2001-04-15 Impact factor: 5.858

8. Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity.

Authors: Carlos Olano; Mohamed S Abdelfattah; Sonia Gullón; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal: Chembiochem Date: 2008-03-03 Impact factor: 3.164

9. Decreased resistance to N,N-dimethylated anthracyclines in multidrug-resistant Friend erythroleukemia cells.

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Journal: Cancer Chemother Pharmacol Date: 1993 Impact factor: 3.333

10. Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules.

Authors: Sean F Brady
Journal: Nat Protoc Date: 2007 Impact factor: 13.491

20 in total

Review 1. Culture-independent discovery of natural products from soil metagenomes.

Authors: Micah Katz; Bradley M Hover; Sean F Brady
Journal: J Ind Microbiol Biotechnol Date: 2015-11-19 Impact factor: 3.346

Review 2. Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products.

Authors: Hahk-Soo Kang
Journal: J Ind Microbiol Biotechnol Date: 2016-11-24 Impact factor: 3.346

Review 3. Heterologous expression-facilitated natural products' discovery in actinomycetes.

Authors: Min Xu; Gerard D Wright
Journal: J Ind Microbiol Biotechnol Date: 2018-11-16 Impact factor: 3.346

Review 4. Using natural products for drug discovery: the impact of the genomics era.

Authors: Mingzi M Zhang; Yuan Qiao; Ee Lui Ang; Huimin Zhao
Journal: Expert Opin Drug Discov Date: 2017-03-14 Impact factor: 6.098

5. 13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus.

Authors: Tomas Gverzdys; Michael Kamin Hart; Sheila Pimentel-Elardo; Geoffrey Tranmer; Justin R Nodwell
Journal: J Antibiot (Tokyo) Date: 2015-05-27 Impact factor: 2.649

6. Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.

Authors: Mikhail Metelev; Jonathan I Tietz; Joel O Melby; Patricia M Blair; Lingyang Zhu; Itamar Livnat; Konstantin Severinov; Douglas A Mitchell
Journal: Chem Biol Date: 2015-01-15

7. Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.

Authors: Min Xu; Yemin Wang; Zhilong Zhao; Guixi Gao; Sheng-Xiong Huang; Qianjin Kang; Xinyi He; Shuangjun Lin; Xiuhua Pang; Zixin Deng; Meifeng Tao
Journal: Appl Environ Microbiol Date: 2016-09-16 Impact factor: 4.792

8. Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.

Authors: Changsheng Wu; Zhuo Shang; Christophe Lemetre; Melinda A Ternei; Sean F Brady
Journal: J Am Chem Soc Date: 2019-02-20 Impact factor: 15.419

9. eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes.

Authors: Boojala Vijay B Reddy; Aleksandr Milshteyn; Zachary Charlop-Powers; Sean F Brady
Journal: Chem Biol Date: 2014-07-24

Review 10. Mining the metabiome: identifying novel natural products from microbial communities.

Authors: Aleksandr Milshteyn; Jessica S Schneider; Sean F Brady
Journal: Chem Biol Date: 2014-09-18