Literature DB >> 26014719

13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus.

Tomas Gverzdys1, Michael Kamin Hart2, Sheila Pimentel-Elardo1, Geoffrey Tranmer2, Justin R Nodwell1.   

Abstract

WAC04657 is a wild-isolate Streptomyces that has antibiotic activities against multidrug-resistant Gram-negative and Gram-positive pathogens. From a solid-agar culture of this organism we isolated 13-deoxytetrodecamycin, a novel antibacterial molecule. It is one of at least three distinct antimicrobial compounds produced by this strain. The molecule has the molecular formula C18H22O5 and is related to the previously discovered compound tetrodecamycin. 13-Deoxytetrodecamycin has potent bioactivity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus.

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Year:  2015        PMID： 26014719     DOI： 10.1038/ja.2015.60

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  29 in total

Review 1.  How many antibiotics are produced by the genus Streptomyces?

Authors:  M G Watve; R Tickoo; M M Jog; B D Bhole
Journal:  Arch Microbiol       Date:  2001-11       Impact factor: 2.552

2.  Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2).

Authors:  Marco Gottelt; Stefan Kol; Juan Pablo Gomez-Escribano; Mervyn Bibb; Eriko Takano
Journal:  Microbiology (Reading)       Date:  2010-05-06       Impact factor: 2.777

3.  Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.

Authors:  Takeshi Hosaka; Mayumi Ohnishi-Kameyama; Hideyuki Muramatsu; Kana Murakami; Yasuhisa Tsurumi; Shinya Kodani; Mitsuru Yoshida; Akihiko Fujie; Kozo Ochi
Journal:  Nat Biotechnol       Date:  2009-04-26       Impact factor: 54.908

4.  MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.

Authors:  Koichiro Tamura; Glen Stecher; Daniel Peterson; Alan Filipski; Sudhir Kumar
Journal:  Mol Biol Evol       Date:  2013-10-16       Impact factor: 16.240

5.  Identifying producers of antibacterial compounds by screening for antibiotic resistance.

Authors:  Maulik N Thaker; Wenliang Wang; Peter Spanogiannopoulos; Nicholas Waglechner; Andrew M King; Ricardo Medina; Gerard D Wright
Journal:  Nat Biotechnol       Date:  2013-09-22       Impact factor: 54.908

Review 6.  Genomic basis for natural product biosynthetic diversity in the actinomycetes.

Authors:  Markus Nett; Haruo Ikeda; Bradley S Moore
Journal:  Nat Prod Rep       Date:  2009-09-01       Impact factor: 13.423

7.  Tetrodecamycin, a new antimicrobial antibiotic from Streptomyces.

Authors:  T Tsuchida; R Sawa; H Iinuma; C Nishida; N Kinoshita; Y Takahashi; H Naganawa; T Sawa; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1994-03       Impact factor: 2.649

8.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

Authors:  S D Bentley; K F Chater; A-M Cerdeño-Tárraga; G L Challis; N R Thomson; K D James; D E Harris; M A Quail; H Kieser; D Harper; A Bateman; S Brown; G Chandra; C W Chen; M Collins; A Cronin; A Fraser; A Goble; J Hidalgo; T Hornsby; S Howarth; C-H Huang; T Kieser; L Larke; L Murphy; K Oliver; S O'Neil; E Rabbinowitsch; M-A Rajandream; K Rutherford; S Rutter; K Seeger; D Saunders; S Sharp; R Squares; S Squares; K Taylor; T Warren; A Wietzorrek; J Woodward; B G Barrell; J Parkhill; D A Hopwood
Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

9.  Derivatives of tetrodecamycin.

Authors:  T Tsuchida; H Iinuma; K T Nakamura; H Nakamura; T Sawa; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1995-11       Impact factor: 2.649

10.  Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.

Authors:  Hahk-Soo Kang; Sean F Brady
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-03       Impact factor: 15.336
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  2 in total

1.  Biosynthetic Genes for the Tetrodecamycin Antibiotics.

Authors:  Tomas Gverzdys; Justin R Nodwell
Journal:  J Bacteriol       Date:  2016-06-27       Impact factor: 3.490

2.  Characterization and partial purification of an antibacterial agent from halophilic actinomycetes Kocuria sp. strain rsk4.

Authors:  Ravi Ranjan Kumar; Vasantba J Jadeja
Journal:  Bioimpacts       Date:  2018-05-01
  2 in total

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