Literature DB >> 24006204

Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.

Najat Haj-Yahya1, Mahmood Haj-Yahya, Carlos A Castañeda, Liat Spasser, Hosahalli P Hemantha, Muhammad Jbara, Marlin Penner, Aaron Ciechanover, David Fushman, Ashraf Brik.   

Abstract

In every direction: Chemical protein synthesis allows the construction of 14 di-ubiquitin analogues modified in the vicinity of the isopeptide bond to examine their behavior with deubiquitinases and ubiquitin binding domains. The results set the ground for the generation of unique probes for studying the interactions of these chains with various ubiquitin-interacting proteins.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  deubiquitinases; peptide ligation; protein synthesis; ubiquitin chains; ubiquitination

Mesh：

Substances：

Year:  2013        PMID： 24006204      PMCID： PMC3904769          DOI： 10.1002/anie.201306118

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  32 in total

1.  Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding.

Authors:  Nadine D Weikart; Stefanie Sommer; Henning D Mootz
Journal:  Chem Commun (Camb)       Date:  2011-11-18       Impact factor: 6.222

Review 2.  Chemistry and biology of the ubiquitin signal.

Authors:  Liat Spasser; Ashraf Brik
Journal:  Angew Chem Int Ed Engl       Date:  2012-06-13       Impact factor: 15.336

Review 3.  Mechanisms, biology and inhibitors of deubiquitinating enzymes.

Authors:  Kerry Routenberg Love; André Catic; Christian Schlieker; Hidde L Ploegh
Journal:  Nat Chem Biol       Date:  2007-11       Impact factor: 15.040

4.  Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains.

Authors:  Yusuke Sato; Azusa Yoshikawa; Atsushi Yamagata; Hisatoshi Mimura; Masami Yamashita; Kayoko Ookata; Osamu Nureki; Kazuhiro Iwai; Masayuki Komada; Shuya Fukai
Journal:  Nature       Date:  2008-08-31       Impact factor: 49.962

5.  N-methylation of isopeptide bond as a strategy to resist deubiquitinases.

Authors:  Mahmood Haj-Yahya; Najat Eltarteer; Shimrit Ohayon; Efrat Shema; Eran Kotler; Moshe Oren; Ashraf Brik
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-12       Impact factor: 15.336

6.  Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme.

Authors:  Carlos Castañeda; Jia Liu; Apurva Chaturvedi; Urszula Nowicka; T Ashton Cropp; David Fushman
Journal:  J Am Chem Soc       Date:  2011-10-19       Impact factor: 15.419

Review 7.  Unraveling the complexity of ubiquitin signaling.

Authors:  Eric R Strieter; David A Korasick
Journal:  ACS Chem Biol       Date:  2012-01-11       Impact factor: 5.100

8.  Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells.

Authors:  Neri Minsky; Efrat Shema; Yair Field; Meromit Schuster; Eran Segal; Moshe Oren
Journal:  Nat Cell Biol       Date:  2008-03-16       Impact factor: 28.824

9.  N-methylation of peptides: a new perspective in medicinal chemistry.

Authors:  Jayanta Chatterjee; Chaim Gilon; Amnon Hoffman; Horst Kessler
Journal:  Acc Chem Res       Date:  2008-07-18       Impact factor: 22.384

10.  Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors:  Yu Ye; Georg Blaser; Mathew H Horrocks; Maria J Ruedas-Rama; Shehu Ibrahim; Alexander A Zhukov; Angel Orte; David Klenerman; Sophie E Jackson; David Komander
Journal:  Nature       Date:  2012-12-02       Impact factor: 49.962
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  7 in total

Review 1.  Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.

Authors:  Grace H Pham; Eric R Strieter
Journal:  Curr Opin Chem Biol       Date:  2015-06-18       Impact factor: 8.822

2.  Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy.

Authors:  Xiaohui Zhao; Maite Mißun; Tobias Schneider; Franziska Müller; Joachim Lutz; Martin Scheffner; Andreas Marx; Michael Kovermann
Journal:  Chembiochem       Date:  2019-06-24       Impact factor: 3.164

Review 3.  Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond.

Authors:  Bo Zhao; Yien Che Tsai; Bo Jin; Bufan Wang; Yiyang Wang; Han Zhou; Tomaya Carpenter; Allan M Weissman; Jun Yin
Journal:  Pharmacol Rev       Date:  2020-04       Impact factor: 25.468

4.  Probing the cell delivery of synthetic diubiquitin chains.

Authors:  Shaswati Mandal; Ashraf Brik
Journal:  Chem Commun (Camb)       Date:  2022-08-04       Impact factor: 6.065

5.  Genetically Directed Production of Recombinant, Isosteric and Nonhydrolysable Ubiquitin Conjugates.

Authors:  Mathew Stanley; Satpal Virdee
Journal:  Chembiochem       Date:  2016-06-27       Impact factor: 3.164

Review 6.  Chemical ubiquitination for decrypting a cellular code.

Authors:  Mathew Stanley; Satpal Virdee
Journal:  Biochem J       Date:  2016-05-15       Impact factor: 3.857

7.  Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions.

Authors:  Emad Eid; Gábor N Boross; Hao Sun; Muna Msallam; Sumeet K Singh; Ashraf Brik
Journal:  Bioconjug Chem       Date:  2020-02-24       Impact factor: 4.774
  7 in total

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