Literature DB >> 22095407

Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding.

Nadine D Weikart1, Stefanie Sommer, Henning D Mootz.   

Abstract

A new route to the synthesis of triazole-linked ubiquitin dimers (diUbs) as structural analogs of the seven diUbs is reported. Binding studies with the Lys48-specific UBA domain of the Mud1 protein suggest that they represent functionally suitable surrogates of their native counterparts linked by an isopeptide bond. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22095407     DOI： 10.1039/c1cc15834a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  21 in total

1.  Preparation of unnatural N-to-N and C-to-C protein fusions.

Authors:  Martin D Witte; Juan J Cragnolini; Stephanie K Dougan; Nicholas C Yoder; Maximilian W Popp; Hidde L Ploegh
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-09       Impact factor: 11.205

2.  Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation.

Authors:  Daniel Rösner; Tatjana Schneider; Daniel Schneider; Martin Scheffner; Andreas Marx
Journal:  Nat Protoc       Date:  2015-09-24       Impact factor: 13.491

Review 3.  Studies of biochemical crosstalk in chromatin with semisynthetic histones.

Authors:  Calvin Jon Antolin Leonen; Esha Upadhyay; Champak Chatterjee
Journal:  Curr Opin Chem Biol       Date:  2018-02-27       Impact factor: 8.822

4.  Proteome-wide identification of ubiquitin interactions using UbIA-MS.

Authors:  Xiaofei Zhang; Arne H Smits; Gabrielle Ba van Tilburg; Huib Ovaa; Wolfgang Huber; Michiel Vermeulen
Journal:  Nat Protoc       Date:  2018-02-15       Impact factor: 13.491

5.  Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.

Authors:  Najat Haj-Yahya; Mahmood Haj-Yahya; Carlos A Castañeda; Liat Spasser; Hosahalli P Hemantha; Muhammad Jbara; Marlin Penner; Aaron Ciechanover; David Fushman; Ashraf Brik
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-04       Impact factor: 15.336

Review 6.  Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.

Authors:  Grace H Pham; Eric R Strieter
Journal:  Curr Opin Chem Biol       Date:  2015-06-18       Impact factor: 8.822

7.  Forging isopeptide bonds using thiol-ene chemistry: site-specific coupling of ubiquitin molecules for studying the activity of isopeptidases.

Authors:  Ellen M Valkevich; Robert G Guenette; Nicholas A Sanchez; Yi-chen Chen; Ying Ge; Eric R Strieter
Journal:  J Am Chem Soc       Date:  2012-04-17       Impact factor: 15.419

8.  Modular assembly of dimeric HIV fusion inhibitor peptides with enhanced antiviral potency.

Authors:  Junpeng Xiao; Thomas J Tolbert
Journal:  Bioorg Med Chem Lett       Date:  2013-09-20       Impact factor: 2.823

9.  Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies.

Authors:  Emma K Dixon; Carlos A Castañeda; Tanuja R Kashyap; Yan Wang; David Fushman
Journal:  Bioorg Med Chem       Date:  2013-03-15       Impact factor: 3.641

Review 10.  Chemical strategies to understand the language of ubiquitin signaling.

Authors:  Caroline E Weller; Meagan E Pilkerton; Champak Chatterjee
Journal:  Biopolymers       Date:  2014-02       Impact factor: 2.505
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