Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.

Literature DB >> 26093241

Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.

Abstract

Covalent attachment of ubiquitin, a process termed ubiquitination, affects the location, function, and stability of modified proteins. Significant advances have been made in building synthetic ubiquitin-protein conjugates that can be used to investigate how ubiquitin regulates diverse biological processes. Herein we describe recent advances and discuss how chemical methods have been implemented to address the molecular underpinnings of ubiquitin-dependent cellular signaling.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Proteins
Ubiquitin

Year: 2015 PMID： 26093241 PMCID： PMC4624511 DOI： 10.1016/j.cbpa.2015.06.001

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

69 in total

Review 1. Ubiquitin: same molecule, different degradation pathways.

Authors: Michael J Clague; Sylvie Urbé
Journal: Cell Date: 2010-11-24 Impact factor: 41.582

2. Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

Authors: Stephanie Panier; Yosuke Ichijima; Amélie Fradet-Turcotte; Charles C Y Leung; Lilia Kaustov; Cheryl H Arrowsmith; Daniel Durocher
Journal: Mol Cell Date: 2012-06-27 Impact factor: 17.970

Review 3. The spatial and temporal organization of ubiquitin networks.

Authors: Caroline Grabbe; Koraljka Husnjak; Ivan Dikic
Journal: Nat Rev Mol Cell Biol Date: 2011-03-30 Impact factor: 94.444

4. Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.

Authors: Najat Haj-Yahya; Mahmood Haj-Yahya; Carlos A Castañeda; Liat Spasser; Hosahalli P Hemantha; Muhammad Jbara; Marlin Penner; Aaron Ciechanover; David Fushman; Ashraf Brik
Journal: Angew Chem Int Ed Engl Date: 2013-09-04 Impact factor: 15.336

5. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Authors: Atsuo T Sasaki; Arkaitz Carracedo; Jason W Locasale; Dimitrios Anastasiou; Koh Takeuchi; Emily Rose Kahoud; Sasson Haviv; John M Asara; Pier Paolo Pandolfi; Lewis C Cantley
Journal: Sci Signal Date: 2011-03-08 Impact factor: 8.192

6. Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response.

Authors: Susan E Tsutakawa; Chunli Yan; Xiaojun Xu; Christopher P Weinacht; Bret D Freudenthal; Kun Yang; Zhihao Zhuang; M Todd Washington; John A Tainer; Ivaylo Ivanov
Journal: Structure Date: 2015-03-12 Impact factor: 5.006

7. Facile synthesis of native and protease-resistant ubiquitylated peptides.

Authors: Caroline E Weller; Wei Huang; Champak Chatterjee
Journal: Chembiochem Date: 2014-05-18 Impact factor: 3.164

8. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

Authors: Tycho E T Mevissen; Manuela K Hospenthal; Paul P Geurink; Paul R Elliott; Masato Akutsu; Nadia Arnaudo; Reggy Ekkebus; Yogesh Kulathu; Tobias Wauer; Farid El Oualid; Stefan M V Freund; Huib Ovaa; David Komander
Journal: Cell Date: 2013-07-03 Impact factor: 41.582

9. K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.

Authors: Yosua Adi Kristariyanto; Syed Arif Abdul Rehman; David G Campbell; Nicholas A Morrice; Clare Johnson; Rachel Toth; Yogesh Kulathu
Journal: Mol Cell Date: 2015-03-05 Impact factor: 17.970

10. Assembly, analysis and architecture of atypical ubiquitin chains.

Authors: Manuela K Hospenthal; Stefan M V Freund; David Komander
Journal: Nat Struct Mol Biol Date: 2013-04-07 Impact factor: 15.369

11 in total

1. Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities.

Authors: Grace H Pham; Ambar S J B Rana; E Nihal Korkmaz; Vivian H Trang; Qiang Cui; Eric R Strieter
Journal: Protein Sci Date: 2016-01-12 Impact factor: 6.725

2. Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

Authors: Yuka E Lewis; Tharindumala Abeywardana; Yu Hsuan Lin; Ana Galesic; Matthew R Pratt
Journal: ACS Chem Biol Date: 2016-01-12 Impact factor: 5.100

3. Reprogramming a Deubiquitinase into a Transamidase.

Authors: Lin Hui Chang; Eric R Strieter
Journal: ACS Chem Biol Date: 2018-09-06 Impact factor: 5.100

4. Determining Atomistic SAXS Models of Tri-Ubiquitin Chains from Bayesian Analysis of Accelerated Molecular Dynamics Simulations.

Authors: Samuel Bowerman; Ambar S J B Rana; Amy Rice; Grace H Pham; Eric R Strieter; Jeff Wereszczynski
Journal: J Chem Theory Comput Date: 2017-05-17 Impact factor: 6.006