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Literature DB >> 23979578

Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans.

Abstract

We have achieved targeted heritable genome modification in Caenorhabditis elegans by injecting mRNA of the nuclease Cas9 and Cas9 guide RNAs. This system rapidly creates precise genomic changes, including knockouts and transgene-instructed gene conversion.

Entities: Chemical

Keywords: CRISPR; Caenorhabditis elegans; Cas9; gene conversion; genome editing; homologous recombination

Mesh：

Substances：

Year: 2013 PMID： 23979578 PMCID： PMC3813846 DOI： 10.1534/genetics.113.155754

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

35 in total

1. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila.

Authors: Zhongsheng Yu; Mengda Ren; Zhanxiang Wang; Bo Zhang; Yikang S Rong; Renjie Jiao; Guanjun Gao
Journal: Genetics Date: 2013-07-05 Impact factor: 4.562

2. Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks.

Authors: Valérie Robert; Jean-Louis Bessereau
Journal: EMBO J Date: 2006-12-07 Impact factor: 11.598

3. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

Authors: D Gems; A J Sutton; M L Sundermeyer; P S Albert; K V King; M L Edgley; P L Larsen; D L Riddle
Journal: Genetics Date: 1998-09 Impact factor: 4.562

4. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions.

Authors: Te-Wen Lo; Catherine S Pickle; Steven Lin; Edward J Ralston; Mark Gurling; Caitlin M Schartner; Qian Bian; Jennifer A Doudna; Barbara J Meyer
Journal: Genetics Date: 2013-08-09 Impact factor: 4.562

5. Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.

Authors: Dhaval S Patel; Acely Garza-Garcia; Manoj Nanji; Joshua J McElwee; Daniel Ackerman; Paul C Driscoll; David Gems
Journal: Genetics Date: 2008-02-01 Impact factor: 4.562

6. Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

Authors: Barbara A Scott; Michael S Avidan; C Michael Crowder
Journal: Science Date: 2002-06-13 Impact factor: 47.728

7. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

Authors: Yanfang Fu; Jennifer A Foden; Cyd Khayter; Morgan L Maeder; Deepak Reyon; J Keith Joung; Jeffry D Sander
Journal: Nat Biotechnol Date: 2013-06-23 Impact factor: 54.908

8. Efficient genome editing in zebrafish using a CRISPR-Cas system.

Authors: Woong Y Hwang; Yanfang Fu; Deepak Reyon; Morgan L Maeder; Shengdar Q Tsai; Jeffry D Sander; Randall T Peterson; J-R Joanna Yeh; J Keith Joung
Journal: Nat Biotechnol Date: 2013-01-29 Impact factor: 54.908

9. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

Authors: Scott J Gratz; Alexander M Cummings; Jennifer N Nguyen; Danielle C Hamm; Laura K Donohue; Melissa M Harrison; Jill Wildonger; Kate M O'Connor-Giles
Journal: Genetics Date: 2013-05-24 Impact factor: 4.562

10. CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans.

Authors: Selma Waaijers; Vincent Portegijs; Jana Kerver; Bennie B L G Lemmens; Marcel Tijsterman; Sander van den Heuvel; Mike Boxem
Journal: Genetics Date: 2013-08-26 Impact factor: 4.562

52 in total

1. Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans.

Authors: Xiangyang Chen; Mu Li; Xuezhu Feng; Shouhong Guang
Journal: Genetics Date: 2015-10-19 Impact factor: 4.562

Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans.

1. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila.

2. Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks.

3. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

4. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions.

5. Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.

6. Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

7. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

8. Efficient genome editing in zebrafish using a CRISPR-Cas system.

9. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

10. CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans.

1. Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans.

2. SapTrap, a Toolkit for High-Throughput CRISPR/Cas9 Gene Modification in Caenorhabditis elegans.

3. Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas.

4. RNA-guided nucleases: a new era for engineering the genomes of model and nonmodel organisms.

Review 5. Exciting prospects for precise engineering of Caenorhabditis elegans genomes with CRISPR/Cas9.

6. Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette.

7. Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design.

8. Strategies for Efficient Genome Editing Using CRISPR-Cas9.

Review 9. CRISPR-Cas systems for editing, regulating and targeting genomes.

Review 10. CRISPR-based technologies: prokaryotic defense weapons repurposed.