Literature DB >> 23940445

Effectiveness of a new inflatable balloon device for gluing dissected layers in an experimental model of aortic dissection.

Necmettin Colak1, Yunus Nazli, Mehmet Fatih Alpay, Ismail Olgun Akkaya, Omer Nuri Aksoy, Sukran Akgedik, Omer Cakir.   

Abstract

OBJECTIVES: In the surgical treatment of acute aortic dissection, tissue glues are widely used to reinforce the adhesion between the dissected aortic layers. A new inflatable balloon device was developed to compress the dissected aortic wall during gluing to increase adhesion between the dissected layers. The present study used an ex vivo experimental animal model to test the hypothesis that this device is effective when gluing the true and false channels of dissected aortas.
METHODS: In the ex vivo experimental model, aortic dissection was simulated surgically on 12 fresh bovine aorta samples. In six samples (group I), the inflatable balloon device was inserted into the aorta to reinforce and fuse the dissected layers during gluing. The other six fresh bovine aortic samples (group II) were compressed between the surgeon's fingers during gluing. Aortic samples were evaluated and compared macroscopically and histologically.
RESULTS: In group I, adhesion between the dissected layers was easily achieved during gluing. All false cavities were perfectly closed, with no deleterious effects related to the device. In group II, the adhesion between the dissected layers was not complete and some false cavities remained patent.
CONCLUSIONS: The inflatable balloon device can increase the adhesive effect of tissue glues via homogenous compression of the dissected aortic layers. In addition, the balloon can prevent distal embolization of the glue.

Entities:  

Keywords:  Aortic dissection; New inflatable balloon device; Tissue gluing

Year:  2013        PMID: 23940445      PMCID: PMC3718600     

Source DB:  PubMed          Journal:  Exp Clin Cardiol        ISSN: 1205-6626


  10 in total

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Authors:  Zahid Mahmood; Debbie S Cook; Heyman Luckraz; Peter O'Keefe
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  10 in total
  1 in total

Review 1.  Experimental in vivo and ex vivo models for the study of human aortic dissection: promises and challenges.

Authors:  Ding-Sheng Jiang; Xin Yi; Xue-Hai Zhu; Xiang Wei
Journal:  Am J Transl Res       Date:  2016-12-15       Impact factor: 4.060

  1 in total

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