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Literature DB >> 28077990

Experimental in vivo and ex vivo models for the study of human aortic dissection: promises and challenges.

Ding-Sheng Jiang¹, Xin Yi², Xue-Hai Zhu¹, Xiang Wei¹.

Abstract

Aortic dissection (AD) is a life-threatening aortopathy with high mortality. To mimic spontaneous AD, investigate the pathogenesis of AD and develop novel therapeutic targets and measures, multiple AD experimental models have been generated, including drugs or chemicals induced experimental models, genetically modified experimental models, surgically or invasively induced experimental models, and ex vivo models. However, the perfect model of AD that replicates every aspect of the natural disease has not be generated yet. This review provides an overview of the experimental models used in AD preclinical research. The value and challenges of each in vivo and ex vivo model are discussed.

Entities: Disease Species

Keywords: Aortic dissection; angiotensin II; experimental model; marfan syndrome; β-aminopropionitrile monofumarate

Year: 2016 PMID： 28077990 PMCID： PMC5209470

Source DB: PubMed Journal: Am J Transl Res Impact factor: 4.060

99 in total

Review 1. Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.

Authors: Dianna M Milewicz; Dong-Chuan Guo; Van Tran-Fadulu; Andrea L Lafont; Christina L Papke; Sakiko Inamoto; Carrie S Kwartler; Hariyadarshi Pannu
Journal: Annu Rev Genomics Hum Genet Date: 2008 Impact factor: 8.929

2. Effectiveness of a new inflatable balloon device for gluing dissected layers in an experimental model of aortic dissection.

Authors: Necmettin Colak; Yunus Nazli; Mehmet Fatih Alpay; Ismail Olgun Akkaya; Omer Nuri Aksoy; Sukran Akgedik; Omer Cakir
Journal: Exp Clin Cardiol Date: 2013

Review 3. Epidemiology of thoracic aortic dissection.

Authors: Scott A LeMaire; Ludivine Russell
Journal: Nat Rev Cardiol Date: 2010-12-21 Impact factor: 32.419

4. Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats.

Authors: A Brüel; G Ortoft; H Oxlund
Journal: Atherosclerosis Date: 1998-09 Impact factor: 5.162

Review 5. Aortic dissection--an update.

Authors: Debabrata Mukherjee; Kim A Eagle
Journal: Curr Probl Cardiol Date: 2005-06 Impact factor: 5.200

Review 6. Update of the UMD-FBN1 mutation database and creation of an FBN1 polymorphism database.

Authors: Gwenaëlle Collod-Béroud; Saga Le Bourdelles; Lesley Ades; Leena Ala-Kokko; Patrick Booms; Maureen Boxer; Anne Child; Paolo Comeglio; Anne De Paepe; James C Hyland; Katerine Holman; Ilkka Kaitila; Bart Loeys; Gabor Matyas; Lieve Nuytinck; Leena Peltonen; Terhi Rantamaki; Peter Robinson; Beat Steinmann; Claudine Junien; Christophe Béroud; Catherine Boileau
Journal: Hum Mutat Date: 2003-09 Impact factor: 4.878

7. Human ex-vivo model of Stanford type B aortic dissection.

Authors: Elsa Madeleine Faure; Ludovic Canaud; Philippe Cathala; Isabelle Serres; Charles Marty-Ané; Pierre Alric
Journal: J Vasc Surg Date: 2013-09-21 Impact factor: 4.268

8. Differences in clinical presentation, management, and outcomes of acute type a aortic dissection in patients with and without previous cardiac surgery.

Authors: J Stewart Collins; Arturo Evangelista; Christoph A Nienaber; Eduardo Bossone; Jianming Fang; Jeanna V Cooper; Dean E Smith; Patrick T O'Gara; Truls Myrmel; Dan Gilon; Eric M Isselbacher; Marc Penn; Linda A Pape; Kim A Eagle; Rajendra H Mehta
Journal: Circulation Date: 2004-09-14 Impact factor: 29.690

9. Patients with Ehlers-Danlos syndrome type IV lack type III collagen.

Authors: F M Pope; G R Martin; J R Lichtenstein; R Penttinen; B Gerson; D W Rowe; V A McKusick
Journal: Proc Natl Acad Sci U S A Date: 1975-04 Impact factor: 11.205

10. The Murine Angiotensin II-Induced Abdominal Aortic Aneurysm Model: Rupture Risk and Inflammatory Progression Patterns.

Authors: Richard Y Cao; Tim Amand; Matthew D Ford; Ugo Piomelli; Colin D Funk
Journal: Front Pharmacol Date: 2010-07-14 Impact factor: 5.810

10 in total

Review 1. From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta.

Authors: Jean-Baptiste Michel; Guillaume Jondeau; Dianna M Milewicz
Journal: Cardiovasc Res Date: 2018-03-15 Impact factor: 10.787

10. Clinical features and risk factors of postoperative in-hospital mortality following surgical repair of Stanford type A acute aortic dissection.

Authors: Chen Ke; Hao Wu; Min Xi; Wei Shi; Qihong Huang; Guirong Lu
Journal: BMC Cardiovasc Disord Date: 2021-08-12 Impact factor: 2.298

10 in total

Experimental in vivo and ex vivo models for the study of human aortic dissection: promises and challenges.

Review 1. Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.

2. Effectiveness of a new inflatable balloon device for gluing dissected layers in an experimental model of aortic dissection.

Review 3. Epidemiology of thoracic aortic dissection.

4. Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats.

Review 5. Aortic dissection--an update.

Review 6. Update of the UMD-FBN1 mutation database and creation of an FBN1 polymorphism database.

7. Human ex-vivo model of Stanford type B aortic dissection.

8. Differences in clinical presentation, management, and outcomes of acute type a aortic dissection in patients with and without previous cardiac surgery.

9. Patients with Ehlers-Danlos syndrome type IV lack type III collagen.

10. The Murine Angiotensin II-Induced Abdominal Aortic Aneurysm Model: Rupture Risk and Inflammatory Progression Patterns.

Review 1. From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta.

2. The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection.

3. Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway^✰.

4. Ginkgolide B for Myocardial Ischemia/Reperfusion Injury: A Preclinical Systematic Review and Meta-Analysis.

5. Changes in aortic collagen in β-aminopropionitrile-induced acute aortic dissection.

Review 6. β-Aminopropionitrile-induced aortic aneurysm and dissection in mice.

7. Computational analysis of aortic haemodynamics in the presence of ascending aortic aneurysm.

8. Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.

9. EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection.

10. Clinical features and risk factors of postoperative in-hospital mortality following surgical repair of Stanford type A acute aortic dissection.