OBJECTIVES: To assess the value of hepatic arterial-phase (HAP) imaging with a low tube voltage (80 kVp), using non-helical, volumetric acquisition with a 320-detector-rows area-detector CT (ADCT) scanner for evaluating hypervascular hepatocellular carcinoma (HCC) compared with routine 120-kVp HAP imaging. METHODS: This study enrolled 128 patients with 148 HCCs. Seventy-six patients with 79 HCCs underwentHAP imaging with 80 kVp obtained using a 320-detector-rows ADCT scanner. The remaining 52 patients with 69 HCCs underwentroutine HAP imaging with 120 kVp obtained by 64-slice helical acquisition. Image noise and tumor to liver contrast-to-noise ratio (CNR) of the two sets of images were compared. Three radiologists evaluated both sets of images using receiver operating characteristic analyses. RESULTS: Although there was a two-fold increase in the mean image noise with 80 kVp over that with 120 kVp (p < 0.001), no significant differences were observed in CNR among the two sets. The mean area under the curve (Az value) and the sensitivity for detecting HCC with 80 kVp (0.980, 78/79, respectively) were higher than that of 120 kVp (0.892, 55/69, respectively). CONCLUSIONS:HAP imaging with 80 kVp obtained by an ADCT scanner significantly improves the diagnostic performance for evaluating hypervascular HCC.
RCT Entities:
OBJECTIVES: To assess the value of hepatic arterial-phase (HAP) imaging with a low tube voltage (80 kVp), using non-helical, volumetric acquisition with a 320-detector-rows area-detector CT (ADCT) scanner for evaluating hypervascular hepatocellular carcinoma (HCC) compared with routine 120-kVp HAP imaging. METHODS: This study enrolled 128 patients with 148 HCCs. Seventy-six patients with 79 HCCs underwent HAP imaging with 80 kVp obtained using a 320-detector-rows ADCT scanner. The remaining 52 patients with 69 HCCs underwent routine HAP imaging with 120 kVp obtained by 64-slice helical acquisition. Image noise and tumor to liver contrast-to-noise ratio (CNR) of the two sets of images were compared. Three radiologists evaluated both sets of images using receiver operating characteristic analyses. RESULTS: Although there was a two-fold increase in the mean image noise with 80 kVp over that with 120 kVp (p < 0.001), no significant differences were observed in CNR among the two sets. The mean area under the curve (Az value) and the sensitivity for detecting HCC with 80 kVp (0.980, 78/79, respectively) were higher than that of 120 kVp (0.892, 55/69, respectively). CONCLUSIONS: HAP imaging with 80 kVp obtained by an ADCT scanner significantly improves the diagnostic performance for evaluating hypervascular HCC.
Authors: Daniele Marin; Rendon C Nelson; Huiman Barnhart; Sebastian T Schindera; Lisa M Ho; Tracy A Jaffe; Terry T Yoshizumi; Richard Youngblood; Ehsan Samei Journal: Radiology Date: 2010-08 Impact factor: 11.105
Authors: Daniele Marin; Rendon C Nelson; Ehsan Samei; Erik K Paulson; Lisa M Ho; Daniel T Boll; David M DeLong; Terry T Yoshizumi; Sebastian T Schindera Journal: Radiology Date: 2009-04-03 Impact factor: 11.105
Authors: Daniele Marin; Rendon C Nelson; Sebastian T Schindera; Samuel Richard; Richard S Youngblood; Terry T Yoshizumi; Ehsan Samei Journal: Radiology Date: 2010-01 Impact factor: 11.105