OBJECTIVE: To compare the effect of implanted medical materials on (18)F-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/MRI using a Dixon-based segmentation method for MRI-based attenuation correction (MRAC), PET/CT and CT-based attenuation-corrected PET (PETCTAC). METHODS: 12 patients (8 males and 4 females; age 58±11 years) with implanted medical materials prospectively underwent whole-body (18)F-FDG PET/CT and PET/MRI. CT, MRI and MRAC maps as well as PETCTAC and PETMRAC images were reviewed for the presence of artefacts. Their morphology and effect on the estimation of the (18)F-FDG uptake (no effect, underestimation, overestimation compared with non-corrected images) were compared. In PETMRAC images, a volume of interest was drawn in the area of the artefact and in a reference site (contralateral body part); the mean and maximum standardised uptake values (SUVmean; SUVmax) were measured. RESULTS: Of 27 implanted materials (20 dental fillings, 3 injection ports, 3 hip prostheses and 1 sternal cerclage), 27 (100%) caused artefacts in CT, 19 (70%) in T1 weighted MRI and 17 (63%) in MRAC maps. 20 (74%) caused a visual overestimation of the (18)F-FDG uptake in PETCTAC, 2 (7%) caused an underestimation and 5 (19%) had no effect. In PETMRAC, 19 (70%) caused spherical extinctions and 8 (30%) had no effect. Mean values for SUVmean and SUVmax were significantly decreased in artefact-harbouring sites (p<0.001). CONCLUSION: Contrary to PET attenuation correction artefacts in PET/CT, which often show an overestimation of the (18)F-FDG uptake, MRAC artefacts owing to implanted medical materials in most cases cause an underestimation. ADVANCES IN KNOWLEDGE: Being aware of the morphology of artefacts owing to implanted medical materials avoids interpretation errors when reading PET/MRI.
OBJECTIVE: To compare the effect of implanted medical materials on (18)F-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/MRI using a Dixon-based segmentation method for MRI-based attenuation correction (MRAC), PET/CT and CT-based attenuation-corrected PET (PETCTAC). METHODS: 12 patients (8 males and 4 females; age 58±11 years) with implanted medical materials prospectively underwent whole-body (18)F-FDG PET/CT and PET/MRI. CT, MRI and MRAC maps as well as PETCTAC and PETMRAC images were reviewed for the presence of artefacts. Their morphology and effect on the estimation of the (18)F-FDG uptake (no effect, underestimation, overestimation compared with non-corrected images) were compared. In PETMRAC images, a volume of interest was drawn in the area of the artefact and in a reference site (contralateral body part); the mean and maximum standardised uptake values (SUVmean; SUVmax) were measured. RESULTS: Of 27 implanted materials (20 dental fillings, 3 injection ports, 3 hip prostheses and 1 sternal cerclage), 27 (100%) caused artefacts in CT, 19 (70%) in T1 weighted MRI and 17 (63%) in MRAC maps. 20 (74%) caused a visual overestimation of the (18)F-FDG uptake in PETCTAC, 2 (7%) caused an underestimation and 5 (19%) had no effect. In PETMRAC, 19 (70%) caused spherical extinctions and 8 (30%) had no effect. Mean values for SUVmean and SUVmax were significantly decreased in artefact-harbouring sites (p<0.001). CONCLUSION: Contrary to PET attenuation correction artefacts in PET/CT, which often show an overestimation of the (18)F-FDG uptake, MRAC artefacts owing to implanted medical materials in most cases cause an underestimation. ADVANCES IN KNOWLEDGE: Being aware of the morphology of artefacts owing to implanted medical materials avoids interpretation errors when reading PET/MRI.
Authors: Vincent Keereman; Yves Fierens; Tom Broux; Yves De Deene; Max Lonneux; Stefaan Vandenberghe Journal: J Nucl Med Date: 2010-05 Impact factor: 10.057
Authors: Gerhard W Goerres; Thomas F Hany; Ehab Kamel; Gustav K von Schulthess; Alfred Buck Journal: Eur J Nucl Med Mol Imaging Date: 2002-03 Impact factor: 9.236
Authors: Gerhard W Goerres; Sibylle I Ziegler; Cyrill Burger; Thomas Berthold; Gustav K Von Schulthess; Alfred Buck Journal: Radiology Date: 2003-02 Impact factor: 11.105
Authors: Jeanne M Gunzinger; Gaspar Delso; Andreas Boss; Miguel Porto; Helen Davison; Gustav K von Schulthess; Martin Huellner; Paul Stolzmann; Patrick Veit-Haibach; Irene A Burger Journal: EJNMMI Phys Date: 2014-12-20
Authors: Claes N Ladefoged; Adam E Hansen; Sune H Keller; Barbara M Fischer; Jacob H Rasmussen; Ian Law; Andreas Kjær; Liselotte Højgaard; Francois Lauze; Thomas Beyer; Flemming L Andersen Journal: EJNMMI Phys Date: 2015-03-11