Literature DB >> 23508174

The why and how of phenotypic small-molecule screens.

Ulrike S Eggert1.   

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Year:  2013        PMID: 23508174     DOI: 10.1038/nchembio.1206

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN: 1552-4450            Impact factor:   15.040


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  24 in total

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4.  Dynasore, a cell-permeable inhibitor of dynamin.

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5.  Too many roads not taken.

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6.  The art of the chemical probe.

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7.  Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

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Review 8.  Small molecule probes of cellular pathways and networks.

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9.  Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis.

Authors:  Adam B Castoreno; Yegor Smurnyy; Angelica D Torres; Martha S Vokes; Thouis R Jones; Anne E Carpenter; Ulrike S Eggert
Journal:  Nat Chem Biol       Date:  2010-05-02       Impact factor: 15.040

10.  Colloidal aggregation affects the efficacy of anticancer drugs in cell culture.

Authors:  Shawn C Owen; Allison K Doak; Pascal Wassam; Molly S Shoichet; Brian K Shoichet
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Review 7.  Small molecule screening in human induced pluripotent stem cell-derived terminal cell types.

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Review 8.  Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.

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9.  Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.

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Review 10.  Turning liabilities into opportunities: Off-target based drug repurposing in cancer.

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