Literature DB >> 12498880

Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton.

Jeffrey R Peterson1, Timothy J Mitchison.   

Abstract

Chemical inhibitors, whether natural products or synthetic, have had an enormous impact on the study of the eukaryotic cytoskeleton. Here we review the history of some of the most widely used cytoskeletal poisons and their influence on our understanding of cytoskeletal functions. We then highlight several new inhibitors and the targeted screens used to identify them and discuss why this approach has been successful.

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Year:  2002        PMID： 12498880     DOI： 10.1016/s1074-5521(02)00284-3

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  90 in total

1.  Inhibition of SRC family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development.

Authors:  Yves Jossin; Masuhara Ogawa; Christine Metin; Fadel Tissir; André M Goffinet
Journal:  J Neurosci       Date:  2003-10-29       Impact factor: 6.167

2.  A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii.

Authors:  Kimberly L Carey; Nicholas J Westwood; Timothy J Mitchison; Gary E Ward
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

3.  Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.

Authors:  Danielle N Margalit; Laura Romberg; Rebecca B Mets; Alan M Hebert; Timothy J Mitchison; Marc W Kirschner; Debabrata RayChaudhuri
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-02       Impact factor: 11.205

4.  Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

Authors:  Heiko Dückert; Verena Pries; Vivek Khedkar; Sascha Menninger; Hanna Bruss; Alexander W Bird; Zoltan Maliga; Andreas Brockmeyer; Petra Janning; Anthony Hyman; Stefan Grimme; Markus Schürmann; Hans Preut; Katja Hübel; Slava Ziegler; Kamal Kumar; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2011-12-25       Impact factor: 15.040

5.  Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells.

Authors:  Eva K B Pfannes; Matthias Theves; Christian Wegner; Carsten Beta
Journal:  J Muscle Res Cell Motil       Date:  2012-03-11       Impact factor: 2.698

6.  The natural product cucurbitacin E inhibits depolymerization of actin filaments.

Authors:  Pia M Sörensen; Roxana E Iacob; Marco Fritzsche; John R Engen; William M Brieher; Guillaume Charras; Ulrike S Eggert
Journal:  ACS Chem Biol       Date:  2012-07-09       Impact factor: 5.100

7.  The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.

Authors:  Charles E Laurent; Frank J Delfino; Haiyun Y Cheng; Thomas E Smithgall
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

8.  Actin-aggregating cucurbitacins from Physocarpus capitatus.

Authors:  Katherine N Maloney; Masaki Fujita; Ulrike S Eggert; Frank C Schroeder; Christine M Field; Timothy J Mitchison; Jon Clardy
Journal:  J Nat Prod       Date:  2008-10-29       Impact factor: 4.050

Review 9.  Making the cut: the chemical biology of cytokinesis.

Authors:  G Ekin Atilla-Gokcumen; Adam B Castoreno; Sofia Sasse; Ulrike S Eggert
Journal:  ACS Chem Biol       Date:  2010-01-15       Impact factor: 5.100

10.  Formation and disassembly of adherens and tight junctions in the corneal endothelium: regulation by actomyosin contraction.

Authors:  Charanya Ramachandran; Sangly P Srinivas
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-12-17       Impact factor: 4.799
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