Literature DB >> 20154659

The art of the chemical probe.

Stephen V Frye1.   

Abstract

Year:  2010        PMID: 20154659     DOI: 10.1038/nchembio.296

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN: 1552-4450            Impact factor:   15.040


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  13 in total

1.  A quantitative analysis of kinase inhibitor selectivity.

Authors:  Mazen W Karaman; Sanna Herrgard; Daniel K Treiber; Paul Gallant; Corey E Atteridge; Brian T Campbell; Katrina W Chan; Pietro Ciceri; Mindy I Davis; Philip T Edeen; Raffaella Faraoni; Mark Floyd; Jeremy P Hunt; Daniel J Lockhart; Zdravko V Milanov; Michael J Morrison; Gabriel Pallares; Hitesh K Patel; Stephanie Pritchard; Lisa M Wodicka; Patrick P Zarrinkar
Journal:  Nat Biotechnol       Date:  2008-01       Impact factor: 54.908

2.  Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Authors:  William A Weiss; Stephen S Taylor; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2007-12       Impact factor: 15.040

3.  Inhibitors paradoxically prime kinases.

Authors:  Stephen V Frye; Gary L Johnson
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040

4.  Molecular biology. Industrial-style screening meets academic biology.

Authors:  Jocelyn Kaiser
Journal:  Science       Date:  2008-08-08       Impact factor: 47.728

5.  Open access chemical and clinical probes to support drug discovery.

Authors:  Aled M Edwards; Chas Bountra; David J Kerr; Timothy M Willson
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040

Review 6.  Target profiling of small molecules by chemical proteomics.

Authors:  Uwe Rix; Giulio Superti-Furga
Journal:  Nat Chem Biol       Date:  2009-09       Impact factor: 15.040

7.  A crowdsourcing evaluation of the NIH chemical probes.

Authors:  Tudor I Oprea; Cristian G Bologa; Scott Boyer; Ramona F Curpan; Robert C Glen; Andrew L Hopkins; Christopher A Lipinski; Garland R Marshall; Yvonne C Martin; Liliana Ostopovici-Halip; Gilbert Rishton; Oleg Ursu; Roy J Vaz; Chris Waller; Herbert Waldmann; Larry A Sklar
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040

8.  PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

Authors:  Angus J M Cameron; Cristina Escribano; Adrian T Saurin; Brenda Kostelecky; Peter J Parker
Journal:  Nat Struct Mol Biol       Date:  2009-05-24       Impact factor: 15.369

9.  On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine.

Authors:  Duangrudee Tanramluk; Adrian Schreyer; William R Pitt; Tom L Blundell
Journal:  Chem Biol Drug Des       Date:  2009-07       Impact factor: 2.817

10.  Inhibitor hijacking of Akt activation.

Authors:  Tatsuya Okuzumi; Dorothea Fiedler; Chao Zhang; Daniel C Gray; Brian Aizenstein; Randy Hoffman; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2009-05-24       Impact factor: 15.040

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  156 in total

1.  Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.

Authors:  Eduard Sergienko; Jian Xu; Wallace H Liu; Russell Dahl; David A Critton; Ying Su; Brock T Brown; Xochella Chan; Li Yang; Ekaterina V Bobkova; Stefan Vasile; Hongbin Yuan; Justin Rascon; Sharon Colayco; Shyama Sidique; Nicholas D P Cosford; Thomas D Y Chung; Tomas Mustelin; Rebecca Page; Paul J Lombroso; Lutz Tautz
Journal:  ACS Chem Biol       Date:  2011-11-17       Impact factor: 5.100

2.  PubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem.

Authors:  Stephanie A Canny; Yasel Cruz; Mark R Southern; Patrick R Griffin
Journal:  Bioinformatics       Date:  2011-11-13       Impact factor: 6.937

3.  Development of a comprehensive set of P2 receptor pharmacological research compounds.

Authors:  R A Felix; S Martin; S Pinion; D J Crawford
Journal:  Purinergic Signal       Date:  2011-11-04       Impact factor: 3.765

4.  Identifying mechanism-of-action targets for drugs and probes.

Authors:  Elisabet Gregori-Puigjané; Vincent Setola; Jérôme Hert; Brenda A Crews; John J Irwin; Eugen Lounkine; Lawrence Marnett; Bryan L Roth; Brian K Shoichet
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

Review 5.  PubChem as a public resource for drug discovery.

Authors:  Qingliang Li; Tiejun Cheng; Yanli Wang; Stephen H Bryant
Journal:  Drug Discov Today       Date:  2010-10-21       Impact factor: 7.851

6.  A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

Authors:  H Ümit Kaniskan; Magdalena M Szewczyk; Zhengtian Yu; Mohammad S Eram; Xiaobao Yang; Keith Schmidt; Xiao Luo; Miao Dai; Feng He; Irene Zang; Ying Lin; Steven Kennedy; Fengling Li; Elena Dobrovetsky; Aiping Dong; David Smil; Sun-Joon Min; Melissa Landon; Jennifer Lin-Jones; Xi-Ping Huang; Bryan L Roth; Matthieu Schapira; Peter Atadja; Dalia Barsyte-Lovejoy; Cheryl H Arrowsmith; Peter J Brown; Kehao Zhao; Jian Jin; Masoud Vedadi
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-27       Impact factor: 15.336

7.  Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.

Authors:  Junghyun L Suh; Brian Watts; Jacob I Stuckey; Jacqueline L Norris-Drouin; Stephanie H Cholensky; Bradley M Dickson; Yi An; Sebastian Mathea; Eidarus Salah; Stefan Knapp; Abid Khan; Alexander T Adams; Brian D Strahl; Cari A Sagum; Mark T Bedford; Lindsey I James; Dmitri B Kireev; Stephen V Frye
Journal:  Biochemistry       Date:  2018-03-28       Impact factor: 3.162

8.  Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.

Authors:  Lindsey I James; Victoria K Korboukh; Liubov Krichevsky; Brandi M Baughman; J Martin Herold; Jacqueline L Norris; Jian Jin; Dmitri B Kireev; William P Janzen; Cheryl H Arrowsmith; Stephen V Frye
Journal:  J Med Chem       Date:  2013-09-16       Impact factor: 7.446

9.  Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds.

Authors:  Hao Zhou; Xin Che; Guochen Bao; Na Wang; Li Peng; Kimberly D Barnash; Stephen V Frye; Lindsey I James; Xu Bai
Journal:  Bioorg Med Chem Lett       Date:  2016-08-03       Impact factor: 2.823

10.  Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.

Authors:  Wenyu Yu; Emma J Chory; Amy K Wernimont; Wolfram Tempel; Alex Scopton; Alexander Federation; Jason J Marineau; Jun Qi; Dalia Barsyte-Lovejoy; Joanna Yi; Richard Marcellus; Roxana E Iacob; John R Engen; Carly Griffin; Ahmed Aman; Erno Wienholds; Fengling Li; Javier Pineda; Guillermina Estiu; Tatiana Shatseva; Taraneh Hajian; Rima Al-Awar; John E Dick; Masoud Vedadi; Peter J Brown; Cheryl H Arrowsmith; James E Bradner; Matthieu Schapira
Journal:  Nat Commun       Date:  2012       Impact factor: 14.919

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