Literature DB >> 23508173

Determining target engagement in living systems.

Gabriel M Simon1, Micah J Niphakis, Benjamin F Cravatt.   

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Year:  2013        PMID： 23508173      PMCID： PMC4004587          DOI： 10.1038/nchembio.1211

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  57 in total

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4.  Development of inverse electron demand Diels-Alder ligation and TR-FRET assays for the determination of ligand-protein target occupancy in live cells.

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Review 5.  Epigenetic regulation by endogenous metabolite pharmacology.

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6.  Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

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8.  Quantitative imaging of receptor-ligand engagement in intact live animals.

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10.  Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement.

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