Literature DB >> 23373460

Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.

Judith P Klinman1.   

Abstract

Quantum tunneling and protein dynamics have emerged as important components of enzyme function. This review focuses on soybean lipoxygenase-1, to illustrate how the properties of enzymatic C-H bond activation link protein motions to the fundamental bond making-breaking processes.

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Year:  2013        PMID： 23373460      PMCID： PMC4091948          DOI： 10.1021/bi301504m

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  52 in total

Review 1.  Relating protein motion to catalysis.

Authors:  Sharon Hammes-Schiffer; Stephen J Benkovic
Journal:  Annu Rev Biochem       Date:  2006       Impact factor: 23.643

2.  Chemical achievement and hope for the future.

Authors:  L PAULING
Journal:  Am Sci       Date:  1948-01       Impact factor: 0.548

3.  A 21st century revisionist's view at a turning point in enzymology.

Authors:  Zachary D Nagel; Judith P Klinman
Journal:  Nat Chem Biol       Date:  2009-08       Impact factor: 15.040

Review 4.  The expression of isotope effects on enzyme-catalyzed reactions.

Authors:  D B Northrop
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

5.  Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects.

Authors:  K W Rickert; J P Klinman
Journal:  Biochemistry       Date:  1999-09-21       Impact factor: 3.162

6.  Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase.

Authors:  Sarah J Edwards; Alexander V Soudackov; Sharon Hammes-Schiffer
Journal:  J Phys Chem B       Date:  2010-05-20       Impact factor: 2.991

7.  Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

Authors:  A Kohen; R Cannio; S Bartolucci; J P Klinman
Journal:  Nature       Date:  1999-06-03       Impact factor: 49.962

8.  Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen.

Authors:  Matthew P Meyer; Judith P Klinman
Journal:  J Am Chem Soc       Date:  2010-12-30       Impact factor: 15.419

9.  Evidence for protein radical-mediated nuclear tunneling in fatty acid alpha-oxygenase.

Authors:  Ankur Gupta; Arnab Mukherjee; Kenji Matsui; Justine P Roth
Journal:  J Am Chem Soc       Date:  2008-08-02       Impact factor: 15.419

10.  The role of conformational entropy in molecular recognition by calmodulin.

Authors:  Michael S Marlow; Jakob Dogan; Kendra K Frederick; Kathleen G Valentine; A Joshua Wand
Journal:  Nat Chem Biol       Date:  2010-04-11       Impact factor: 15.040
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  26 in total

1.  Synthesis of Site-Specifically 13C Labeled Linoleic Acids.

Authors:  Adam R Offenbacher; Hui Zhu; Judith P Klinman
Journal:  Tetrahedron Lett       Date:  2016-08-22       Impact factor: 2.415

2.  Resolution and Characterization of Chemical Steps in Enzyme Catalytic Sequences by Using Low-Temperature and Time-Resolved, Full-Spectrum EPR Spectroscopy in Fluid Cryosolvent and Frozen Solution Systems.

Authors:  Miao Wang; Chen Zhu; Meghan Kohne; Kurt Warncke
Journal:  Methods Enzymol       Date:  2015-09-14       Impact factor: 1.600

3.  A Biophysical Perspective on Enzyme Catalysis.

Authors:  Pratul K Agarwal
Journal:  Biochemistry       Date:  2018-12-18       Impact factor: 3.162

4.  Dynamical network of residue-residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation.

Authors:  Urmi Doshi; Michael J Holliday; Elan Z Eisenmesser; Donald Hamelberg
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-11       Impact factor: 11.205

5.  Reflections on the catalytic power of a TIM-barrel.

Authors:  John P Richard; Xiang Zhai; M Merced Malabanan
Journal:  Bioorg Chem       Date:  2014-07-11       Impact factor: 5.275

6.  Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.

Authors:  Shenshen Hu; Adam R Offenbacher; Erin M Thompson; Christine L Gee; Jarett Wilcoxen; Cody A M Carr; Daniil M Prigozhin; Vanessa Yang; Tom Alber; R David Britt; James S Fraser; Judith P Klinman
Journal:  J Am Chem Soc       Date:  2019-01-15       Impact factor: 15.419

7.  A Reactive Manganese(IV)-Hydroxide Complex: A Missing Intermediate in Hydrogen Atom Transfer by High-Valent Metal-Oxo Porphyrinoid Compounds.

Authors:  Jan Paulo T Zaragoza; Maxime A Siegler; David P Goldberg
Journal:  J Am Chem Soc       Date:  2018-03-15       Impact factor: 15.419

Review 8.  Enzymatic rate enhancements: a review and perspective.

Authors:  John P Richard
Journal:  Biochemistry       Date:  2013-03-14       Impact factor: 3.162

9.  Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C-H Activation by Soybean Lipoxygenase-1.

Authors:  Shenshen Hu; Jérôme Cattin-Ortolá; Jeffrey W Munos; Judith P Klinman
Journal:  Angew Chem Int Ed Engl       Date:  2016-06-27       Impact factor: 15.336

Review 10.  Mammalian lipoxygenases and their biological relevance.

Authors:  Hartmut Kuhn; Swathi Banthiya; Klaus van Leyen
Journal:  Biochim Biophys Acta       Date:  2014-10-12
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