BACKGROUND: Few studies have evaluated the association of diet and weight status with head and neck cancer outcomes. OBJECTIVE: The purpose of this study was to determine whether pretreatment dietary patterns and weight status are associated with head and neck cancer prognosis. DESIGN: This was a longitudinal study of 542 patients with newly diagnosed head and neck cancer who completed food-frequency questionnaires and health surveys before treatment. Clinical data were abstracted from medical records and the Social Security Death Index. Dietary patterns were identified by using principal component analysis. Cox proportional hazard models were used to examine the association of derived dietary patterns (fit by quintiles of exposure) and weight status with time to recurrence and survival, with control for covariates. RESULTS: During the study period, there were 229 deaths and 184 recurrences. Two dietary patterns were identified: a whole-foods pattern (characterized by high intakes of vegetables, fruit, fish, poultry, and whole grains) and a Western pattern (characterized by high intakes of red and processed meats, refined grains, potatoes, and French fries). In multivariable analyses, significantly fewer deaths were observed in subjects most adherent to the whole-foods pattern (HR: 0.56; 95% CI: 0.34, 0.92; P-trend = 0.01). Subjects classified as overweight or obese had significantly fewer deaths (HR: 0.65; 95% CI: 0.49, 0.85; P = 0.001) and recurrences (HR: 0.70; 95% CI: 0.52, 0.95; P = 0.02) than did normal-weight or underweight subjects. CONCLUSION: Consumption of a diet rich in vegetables, fruit, fish, poultry, and whole grains and being overweight before diagnosis with head and neck cancer are associated with a better prognosis.
BACKGROUND: Few studies have evaluated the association of diet and weight status with head and neck cancer outcomes. OBJECTIVE: The purpose of this study was to determine whether pretreatment dietary patterns and weight status are associated with head and neck cancer prognosis. DESIGN: This was a longitudinal study of 542 patients with newly diagnosed head and neck cancer who completed food-frequency questionnaires and health surveys before treatment. Clinical data were abstracted from medical records and the Social Security Death Index. Dietary patterns were identified by using principal component analysis. Cox proportional hazard models were used to examine the association of derived dietary patterns (fit by quintiles of exposure) and weight status with time to recurrence and survival, with control for covariates. RESULTS: During the study period, there were 229 deaths and 184 recurrences. Two dietary patterns were identified: a whole-foods pattern (characterized by high intakes of vegetables, fruit, fish, poultry, and whole grains) and a Western pattern (characterized by high intakes of red and processed meats, refined grains, potatoes, and French fries). In multivariable analyses, significantly fewer deaths were observed in subjects most adherent to the whole-foods pattern (HR: 0.56; 95% CI: 0.34, 0.92; P-trend = 0.01). Subjects classified as overweight or obese had significantly fewer deaths (HR: 0.65; 95% CI: 0.49, 0.85; P = 0.001) and recurrences (HR: 0.70; 95% CI: 0.52, 0.95; P = 0.02) than did normal-weight or underweight subjects. CONCLUSION: Consumption of a diet rich in vegetables, fruit, fish, poultry, and whole grains and being overweight before diagnosis with head and neck cancer are associated with a better prognosis.
Authors: M Sandoval; R Font; M Mañós; M Dicenta; M J Quintana; F X Bosch; X Castellsagué Journal: Int J Oral Maxillofac Surg Date: 2008-10-31 Impact factor: 2.789
Authors: Sharon J Wayne; Susan T Lopez; Lisa M Butler; Kathy B Baumgartner; Richard N Baumgartner; Rachel Ballard-Barbash Journal: J Am Diet Assoc Date: 2004-10
Authors: Sonia A Duffy; David L Ronis; Scott McLean; Karen E Fowler; Stephen B Gruber; Gregory T Wolf; Jeffrey E Terrell Journal: J Clin Oncol Date: 2009-03-16 Impact factor: 44.544
Authors: Catherine M Alfano; Jeannette M Day; Mira L Katz; James E Herndon; Marisa A Bittoni; Jill M Oliveri; Kathleen Donohue; Electra D Paskett Journal: Psychooncology Date: 2009-02 Impact factor: 3.894
Authors: Lisa A Peterson; Emily L Bellile; Gregory T Wolf; Shama Virani; Andrew G Shuman; Jeremy M G Taylor; Laura S Rozek Journal: Head Neck Date: 2016-07-19 Impact factor: 3.147
Authors: Samantha Lang; Sarah Schimansky; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steven Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andrew R Ness Journal: Head Neck Date: 2019-01-30 Impact factor: 3.147
Authors: William G Albergotti; Kara S Davis; Shira Abberbock; Julie E Bauman; James Ohr; David A Clump; Dwight E Heron; Umamaheswar Duvvuri; Seungwon Kim; Jonas T Johnson; Robert L Ferris Journal: Oral Oncol Date: 2016-07-07 Impact factor: 5.337
Authors: Sylvia L Crowder; Kalika P Sarma; Alison M Mondul; Yi Tang Chen; Zonggui Li; M Yanina Pepino; Katie R Zarins; Gregory T Wolf; Laura S Rozek; Anna E Arthur Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-07-17 Impact factor: 4.254
Authors: Anna E Arthur; Emily L Bellile; Laura S Rozek; Karen E Peterson; Jianwei Ren; Ethan Harris; Christie Mueller; Shruti Jolly; Lisa A Peterson; Gregory T Wolf; Zora Djuric Journal: Head Neck Date: 2015-11-28 Impact factor: 3.147
Authors: Gabriel de la Garza; Oleg Militsakh; Aru Panwar; Tabitha L Galloway; Jeffrey B Jorgensen; Levi G Ledgerwood; Katelyn Kaiser; Collin Kitzerow; Yelizaveta Shnayder; Colin A Neumann; Samir S Khariwala; W Chad Spanos; Nitin A Pagedar Journal: Head Neck Date: 2015-08-13 Impact factor: 3.147
Authors: Biljana Gigic; Heiner Boeing; Reka Toth; Jürgen Böhm; Nina Habermann; Dominique Scherer; Petra Schrotz-King; Clare Abbenhardt-Martin; Stephanie Skender; Hermann Brenner; Jenny Chang-Claude; Michael Hoffmeister; Karen Syrjala; Paul B Jacobsen; Martin Schneider; Alexis Ulrich; Cornelia M Ulrich Journal: Nutr Cancer Date: 2017-12-15 Impact factor: 2.900
Authors: Sylvia L Crowder; Andrew D Frugé; Katherine G Douglas; Yi Tang Chen; Laura Moody; Ashley Delk-Licata; John W Erdman; Molly Black; William R Carroll; Sharon A Spencer; Julie L Locher; Wendy Demark-Wahnefried; Laura Q Rogers; Anna E Arthur Journal: J Acad Nutr Diet Date: 2019-01-17 Impact factor: 4.910