William G Albergotti1, Kara S Davis2, Shira Abberbock3, Julie E Bauman4, James Ohr4, David A Clump5, Dwight E Heron6, Umamaheswar Duvvuri7, Seungwon Kim2, Jonas T Johnson2, Robert L Ferris2. 1. Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address: albergottiwg@upmc.edu. 2. Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. 3. Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States. 4. Division Medical Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States. 5. Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States. 6. Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States. 7. Veterans Affairs Pittsburgh Health System, Pittsburgh, PA, United States; Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Abstract
BACKGROUND: Pretreatment body mass index (BMI) >25kg/m(2) is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). METHODS: This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25kg/m(2)). Univariate and multivariate analyses of survival were performed. RESULTS: 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25kg/m(2) had a longer overall survival (HR=0.49, P=0.01) as well as a longer disease-specific survival (HR=0.43, P=0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR=0.54, P=0.04). CONCLUSIONS: Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.
BACKGROUND: Pretreatment body mass index (BMI) >25kg/m(2) is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). METHODS: This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25kg/m(2)). Univariate and multivariate analyses of survival were performed. RESULTS: 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25kg/m(2) had a longer overall survival (HR=0.49, P=0.01) as well as a longer disease-specific survival (HR=0.43, P=0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR=0.54, P=0.04). CONCLUSIONS: Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.
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