Anna E Arthur1,2, Emily L Bellile3,4, Laura S Rozek2,5, Karen E Peterson2,6, Jianwei Ren7, Ethan Harris7, Christie Mueller7, Shruti Jolly8, Lisa A Peterson5, Gregory T Wolf5, Zora Djuric2,7. 1. Department of Nutrition Sciences, University of Alabama-Birmingham, Birmingham, Alabama. 2. Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan. 3. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan. 4. Center for Cancer Biostatistics, University of Michigan, Ann Arbor, Michigan. 5. Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan. 6. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts. 7. Department of Family Medicine, University of Michigan, Ann Arbor, Michigan. 8. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Abstract
BACKGROUND: The purpose of this study was to examine associations of pretreatment serum carotenoids, tocopherols, and quercetin with prognosis in 154 patients newly diagnosed with head and neck cancer. METHODS: Pretreatment blood and health surveys were collected. Serum micronutrients were measured by high performance liquid chromatography. Data on recurrence and death were collected annually. Cox proportional hazards models measured associations of serum nutrient concentrations with recurrence and overall survival. RESULTS: During a median follow-up time of 37 months, there were 32 recurrences and 27 deaths. After controlling for covariates, subjects with high versus low serum xanthophyll and total carotenoid concentrations had significantly longer recurrence-free time (p = .002 and p = .02, respectively). Overall survival time was significantly longer in patients with high versus low serum xanthophyll concentrations (p = .02). CONCLUSION: Future research should evaluate the possible benefits of interventions to increase intakes of rich food sources of xanthophylls in this patient population.
BACKGROUND: The purpose of this study was to examine associations of pretreatment serum carotenoids, tocopherols, and quercetin with prognosis in 154 patients newly diagnosed with head and neck cancer. METHODS: Pretreatment blood and health surveys were collected. Serum micronutrients were measured by high performance liquid chromatography. Data on recurrence and death were collected annually. Cox proportional hazards models measured associations of serum nutrient concentrations with recurrence and overall survival. RESULTS: During a median follow-up time of 37 months, there were 32 recurrences and 27 deaths. After controlling for covariates, subjects with high versus low serum xanthophyll and total carotenoid concentrations had significantly longer recurrence-free time (p = .002 and p = .02, respectively). Overall survival time was significantly longer in patients with high versus low serum xanthophyll concentrations (p = .02). CONCLUSION: Future research should evaluate the possible benefits of interventions to increase intakes of rich food sources of xanthophylls in this patient population.
Authors: Victor Maso; Andrana Karla Calgarotto; Gilberto Carlos Franchi; Alexandre Eduardo Nowill; Paulo Latuf Filho; José Vassallo; Sara Teresinha Olalla Saad Journal: Cancer Prev Res (Phila) Date: 2014-10-07
Authors: M Sandoval; R Font; M Mañós; M Dicenta; M J Quintana; F X Bosch; X Castellsagué Journal: Int J Oral Maxillofac Surg Date: 2008-10-31 Impact factor: 2.789
Authors: Sonia A Duffy; David L Ronis; Scott McLean; Karen E Fowler; Stephen B Gruber; Gregory T Wolf; Jeffrey E Terrell Journal: J Clin Oncol Date: 2009-03-16 Impact factor: 44.544
Authors: Neal D Freedman; Yikyung Park; Amy F Subar; Albert R Hollenbeck; Michael F Leitzmann; Arthur Schatzkin; Christian C Abnet Journal: Int J Cancer Date: 2008-05-15 Impact factor: 7.396
Authors: Anna E Arthur; Karen E Peterson; Laura S Rozek; Jeremy M G Taylor; Emily Light; Douglas B Chepeha; James R Hébert; Jeffrey E Terrell; Gregory T Wolf; Sonia A Duffy Journal: Am J Clin Nutr Date: 2012-12-26 Impact factor: 7.045
Authors: Samantha Lang; Sarah Schimansky; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steven Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andrew R Ness Journal: Head Neck Date: 2019-01-30 Impact factor: 3.147
Authors: Sylvia L Crowder; Kalika P Sarma; Alison M Mondul; Yi Tang Chen; Zonggui Li; M Yanina Pepino; Katie R Zarins; Gregory T Wolf; Laura S Rozek; Anna E Arthur Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-07-17 Impact factor: 4.254
Authors: Sylvia L Crowder; Andrew D Frugé; Katherine G Douglas; Yi Tang Chen; Laura Moody; Ashley Delk-Licata; John W Erdman; Molly Black; William R Carroll; Sharon A Spencer; Julie L Locher; Wendy Demark-Wahnefried; Laura Q Rogers; Anna E Arthur Journal: J Acad Nutr Diet Date: 2019-01-17 Impact factor: 4.910
Authors: Anna E Arthur; Amy M Goss; Wendy Demark-Wahnefried; Alison M Mondul; Kevin R Fontaine; Yi Tang Chen; William R Carroll; Sharon A Spencer; Laura Q Rogers; Laura S Rozek; Gregory T Wolf; Barbara A Gower Journal: Int J Cancer Date: 2018-04-17 Impact factor: 7.396