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Literature DB >> 23162679

The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

Erick A Lindsey¹, Christopher M Brackett, Trey Mullikin, Cristina Alcaraz, Christian Melander.

Abstract

A diverse 23-compound library of N-1 substituted 2-aminobenzimidazoles was synthesized via an efficient three-step process. This small library produced several non-toxic biofilm modulators of two strains of MRSA. Preliminary mechanistic studies reveal a zinc-dependent mode of action for these compounds.

Entities: Chemical Disease Species

Year: 2012 PMID： 23162679 PMCID： PMC3496259 DOI： 10.1039/C2MD20244A

Source DB: PubMed Journal: Medchemcomm ISSN： 2040-2503 Impact factor: 3.597

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1. Antimicrobial resistance: it's not just for hospitals.

Authors: Elizabeth A Bancroft
Journal: JAMA Date: 2007-10-17 Impact factor: 56.272

Review 2. Antimicrobials as a contributory factor in oral candidosis--a brief overview.

Authors: N S Soysa; L P Samaranayake; A N B Ellepola
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3. The bacteria fight back.

Authors: Gary Taubes
Journal: Science Date: 2008-07-18 Impact factor: 47.728

4. Antibiofilm activity of a diverse oroidin library generated through reductive acylation.

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Journal: J Org Chem Date: 2009-02-20 Impact factor: 4.354

5. A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

Authors: Steven A Rogers; Robert W Huigens; Christian Melander
Journal: J Am Chem Soc Date: 2009-07-29 Impact factor: 15.419

6. Inhibition and dispersion of proteobacterial biofilms.

Authors: Justin J Richards; Robert W Huigens Iii; T Eric Ballard; Anne Basso; John Cavanagh; Christian Melander
Journal: Chem Commun (Camb) Date: 2008-02-08 Impact factor: 6.222

7. Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii.

Authors: Zhaoming Su; Lingling Peng; Roberta J Worthington; Christian Melander
Journal: ChemMedChem Date: 2011-09-16 Impact factor: 3.466

8. Regulation of slime production in Staphylococcus epidermidis by iron limitation.

Authors: M Deighton; R Borland
Journal: Infect Immun Date: 1993-10 Impact factor: 3.441

9. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms.

Authors: Deborah G Conrady; Cristin C Brescia; Katsunori Horii; Alison A Weiss; Daniel J Hassett; Andrew B Herr
Journal: Proc Natl Acad Sci U S A Date: 2008-12-01 Impact factor: 11.205

10. The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

Authors: Robert W Huigens; Samuel Reyes; Catherine S Reed; Cynthia Bunders; Steven A Rogers; Andrew T Steinhauer; Christian Melander
Journal: Bioorg Med Chem Date: 2009-12-06 Impact factor: 3.641

12 in total

1. Natural products as inspiration for the development of bacterial antibiofilm agents.

Authors: Roberta J Melander; Akash K Basak; Christian Melander
Journal: Nat Prod Rep Date: 2020-07-01 Impact factor: 13.423

2. Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria.

Authors: William M Huggins; William T Barker; James T Baker; Nicholas A Hahn; Roberta J Melander; Christian Melander
Journal: ACS Med Chem Lett Date: 2018-05-25 Impact factor: 4.345

The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

1. Antimicrobial resistance: it's not just for hospitals.

Review 2. Antimicrobials as a contributory factor in oral candidosis--a brief overview.

3. The bacteria fight back.

4. Antibiofilm activity of a diverse oroidin library generated through reductive acylation.

5. A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

6. Inhibition and dispersion of proteobacterial biofilms.

7. Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii.

8. Regulation of slime production in Staphylococcus epidermidis by iron limitation.

9. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms.

10. The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

1. Natural products as inspiration for the development of bacterial antibiofilm agents.

2. Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria.

3. Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa.

Review 4. Natural Products as Platforms To Overcome Antibiotic Resistance.

5. Anti-biofilm activity of quinazoline derivatives against Mycobacterium smegmatis.

6. Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules.

7. Purification of PIA and rSesC as Putative Vaccine Candidates Against Staphylococcus aureus.

8. Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.

9. PIA and rSesC Mixture Arisen Antibodies Could Inhibit the Biofilm-Formation in Staphylococcus aureus.

10. 2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium.