Literature DB >> 19621946

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

Steven A Rogers1, Robert W Huigens, Christian Melander.   

Abstract

A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococcus epidermidis biofilms. Mechanistic studies showed that the activity is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism.

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Year:  2009        PMID： 19621946     DOI： 10.1021/ja9024676

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  27 in total

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3.  Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner.

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5.  Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles.

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Journal:  Tetrahedron Lett       Date:  2015-10-28       Impact factor: 2.415

6.  Marine sponge alkaloids as a source of anti-bacterial adjuvants.

Authors:  Roberta J Melander; Hong-Bing Liu; Matthew D Stephens; Carole A Bewley; Christian Melander
Journal:  Bioorg Med Chem Lett       Date:  2016-11-09       Impact factor: 2.823

7.  Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents.

Authors:  Steven A Rogers; Robert W Huigens; John Cavanagh; Christian Melander
Journal:  Antimicrob Agents Chemother       Date:  2010-03-08       Impact factor: 5.191

8.  The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

Authors:  Erick A Lindsey; Christopher M Brackett; Trey Mullikin; Cristina Alcaraz; Christian Melander
Journal:  Medchemcomm       Date:  2012-09-18       Impact factor: 3.597

9.  Parallel Solid-Phase Synthesis of disubstituted 3-(1H-benzo[d]imidazol-2-yl)imidazolidine-2,4-diones and 3-(1H-benzo[d]imidazol-2-yl)-2-thioxoimidazolidin-4-ones.

Authors:  Sureshbabu Dadiboyena; Adel Nefzi
Journal:  Tetrahedron Lett       Date:  2011-12-28       Impact factor: 2.415

10.  Surface-mediated release of a small-molecule modulator of bacterial biofilm formation: a non-bactericidal approach to inhibiting biofilm formation in Pseudomonas aeruginosa.

Authors:  Adam H Broderick; Anthony S Breitbach; Reto Frei; Helen E Blackwell; David M Lynn
Journal:  Adv Healthc Mater       Date:  2013-01-20       Impact factor: 9.933
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